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MEF2C

myocyte enhancer factor 2C

Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Gene Name: myocyte enhancer factor 2C
Synonyms: MEF2C, C5DELq14.3, DEL5q14.3, Myocyte enhancer factor 2C
Target Sequences: NM_002397 NP_002388.2 Q06413

Publications (2)

1
Lymphoangiocrine signals promote cardiac growth and repair. Xiaolei Liu, Ester De la Cruz, Xiaowu Gu, Laszlo Balint, Michael Oxendine-Burns, Tamara Terrones, Wanshu Ma, Hui-Hsuan Kuo, Connor Lantz, Trisha Bansal, Edward Thorp, Paul Burridge, Zoltán Jakus, Joachim Herz, Ondine Cleaver, Miguel Torres, Guillermo Oliver. Nature. 2020 December; [Full Text Article] [PubMed:33299187] [PMC:PMC7770123] Related Antibodies: LS-C356188.
2
Downregulated miR-18b-5p triggers apoptosis by inhibition of calcium signaling and neuronal cell differentiation in transgenic SOD1 (G93A) mice and SOD1 (G17S and G86S) ALS patients. Ki Yoon Kim, Yu Ri Kim, Kyung Won Choi, Mijung Lee, Somyung Lee, Wooseok Im, Je-Young Shin, Jin Young Kim, Yoon Ho Hong, Manho Kim, Jong-Il Kim, Jung-Joon Sung. Translational neurodegeneration. 2020 July;9:23. [Full Text Article] [PubMed:32605607] [PMC:PMC7328278] Related Antibodies: LS-C31031.

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MEF2C (6)
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MEF2C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
45.4 kDa
100 µg/$494
MEF2C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
51 kDa
100 µg/$494
MEF2C Protein - 12.5% SDS-PAGE of human MEF2C stained with Coomassie Blue
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Wheat Germ Extract
GST
77.3 kDa
2 µg/$439
MEF2C Protein - Purified recombinant protein MEF2C was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
51 kDa
20 µg/$1,107
MEF2C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
51 kDa
20 µg/$150
MEF2C Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
45.4 kDa
20 µg/$150
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).