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MED28 / Magicin
mediator complex subunit 28
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.
| Gene Name: | mediator complex subunit 28 |
| Synonyms: | MED28, EG1, Endothelial-derived protein 1, DKFZP434N185, Magicin, Mediator complex subunit 28, Tumor angiogenesis marker EG-1, Endothelial-derived gene 1 |
| Target Sequences: | NM_025205 NP_079481.2 Q9H204 |
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