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MED1 / TRAP220
mediator complex subunit 1
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize.
| Gene Name: | mediator complex subunit 1 |
| Synonyms: | MED1, ARC205, CRSP1, DRIP205, DRIP230, Mediator complex subunit 1, PBP, PPARG binding protein, RB18A, TRIP-2, TRIP2, PPARBP, CRSP200, p53 regulatory protein RB18A, PPAR binding protein, PPAR-binding protein, PPARGBP, TR-interacting protein 2, TRAP220 |
| Target Sequences: | NM_004774 NP_004765.2 Q15648 |
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