MDM2

MDM2 oncogene, E3 ubiquitin protein ligase

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation.

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Products

Proteins (10)

Type

Over-Expression Lysate (2)

Recombinant (8)

Target

MDM2 (10)

Publications

No (10)

Tag

GST (1)

GST, N-terminus (1)

His (3)

His, N-Terminal (3)

Myc-DDK (Flag) (2)

Species

Human (7)

Mouse (2)

Source

293T Cells (1)

E. coli (5)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Yeast (1)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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Human MDM2 Protein (Recombinant His, N-Terminal) (aa1-218) - LS-G25788

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

44 kDa by SDS-PAGE

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Mouse MDM2 Protein (Recombinant His) (Full Length) - LS-G23022

Source:

Yeast

Tag:

His

Molecular Weight:

56.5 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Human MDM2 Protein (Recombinant His, N-Terminal) - LS-G145274

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

35.9 kDa

Price:

50 µg/$419

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Human MDM2 Protein (Recombinant GST, N-terminus) (aa101-200) - LS-G59208

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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MDM2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99740

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.8 kDa

Price:

100 µg/$710

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Human MDM2 Protein (Recombinant His, N-Terminal) (Met1-Pro321) - LS-G132825

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

39.7kDa

Price:

10 µg/$335; 50 µg/$775; 200 µg/$1,396; 100 µg/$1,183; 1 mg/$2,687; 500 µg/$2,182; 5 mg/$5,419; 2 mg/$2,891

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Human MDM2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87320

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

55.8 kDa

Price:

20 µg/$215

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Mouse MDM2 Protein (Recombinant His) (Full Length) - LS-G20960

Source:

E. coli

Tag:

His

Molecular Weight:

58.6 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human MDM2 Protein (Recombinant GST) (Full Length) - LS-G29301

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

81.6 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MDM2 Protein (Recombinant His) (aa213-422) - LS-G141160

Source:

E. coli

Sequence Length:

209 AA

Tag:

His

Endotoxin Level:

Less than 0.1 EU/µg protein (determined by LAL method).

Molecular Weight:

23.1 kDa

Price:

10 mg/$4,268; 5 mg/$3,201; 1 mg/$1,868; 0.5 mg/$1,475; 200 µg/$1,103; 100 µg/$756; 50 µg/$531

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