MCTS1

malignant T cell amplified sequence 1

Anti-oncogene that play a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. Involved in translation initiation; promotes recruitment of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role as translation enhancer; recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. Hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. Increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiples chromosomal fusions when overexpressed in gamma-irradiated cells. May play a role in promoting lymphoid tumor development: lymphoid cell lines overexpressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. May contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. Involved in the process of proteasome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; Positively regulates phosphorylation of MAPK1 and MAPK3. Involved in translation initiation; promotes aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits.

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Products

Proteins (7)

Type

Over-Expression Lysate (2)

Recombinant (5)

Target

MCTS1 (7)

Publications

No (7)

Tag

GST (1)

His (1)

His, N-Terminal (1)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (6)

Source

293T Cells (1)

E. coli (3)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human MCTS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85933

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.4 kDa

Price:

20 µg/$150

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Human MCTS1 Protein (Recombinant His, N-Terminal) - LS-G144988

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

20.4 kDa

Price:

50 µg/$419

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MCTS1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114168

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.4 kDa

Price:

100 µg/$494

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Human MCTS1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G69955

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.4 kDa

Price:

20 µg/$1,107

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Human MCTS1 Protein (Recombinant His) - LS-G2211

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human MCTS1 Protein (Recombinant His-SUMO) (Full Length) - LS-G22010

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

36.54 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human MCTS1 Protein (Recombinant GST) (Full Length) - LS-G33372

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

45.65 kDa

Price:

10 µg/$479; 25 µg/$670

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