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MCM3AP / GANP
minichromosome maintenance complex component 3 associated protein
Isoform GANP: Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells (By similarity). Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.
| Gene Name: | minichromosome maintenance complex component 3 associated protein |
| Synonyms: | MCM3AP, 80 kDa MCM3-associated protein, GANP, MAP80, Mcm3 import factor, Protein GANP, MCM3 import protein, KIAA0572, SAC3 |
| Target Sequences: | AB011144 O60318 O60318 |
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