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MCM2

minichromosome maintenance complex component 2

Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division.

Gene Name: minichromosome maintenance complex component 2
Synonyms: MCM2, BM28, Cell devision cycle-like 1, D3S3194, Cdc19, Cyclin-like 1, KIAA0030, Nuclear protein BM28, CDCL1, MITOTIN
Target Sequences: NM_004526 NP_004517.2 P49736

Publications (3)

1
Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing. Wu ZQ, Liu X. Proceedings of the National Academy of Sciences of the United States of America. 2008 105:1919-24. [PubMed:18250300] [PMC:PMC2538859]
2
Plk1 phosphorylation of Orc2 promotes DNA replication under conditions of stress. Song B, Liu XS, Davis K, Liu X. Molecular and cellular biology. 2011 31:4844-56. [PubMed:21947279] [PMC:PMC3232917]
3
The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis. Nascimento EM, Cox CL, MacArthur S, Hussain S, Trotter M, Blanco S, Suraj M, Nichols J, Kbler B, Benitah SA, Hendrich B, Odom DT, Frye M. Nature cell biology. 2011 13:1395-405. (IHC-P; Mouse) [Full Text Article] [PubMed:22101514] [PMC:PMC3242072] Related Antibodies: LS-B391.

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ELISA Kits (5)
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MCM2 (5)
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MCM2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$798
MCM2 ELISA Kit
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Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$783
MCM2 ELISA Kit
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Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
MCM2 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
78 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
MCM2 ELISA Kit
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Cell-Based
96-Well Microplate
Mouse, Human
Colorimetric - 450nm (TMB)
Adherent Cell Cultures
1 Plate/$618
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).