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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MCL1 / MCL 1

myeloid cell leukemia sequence 1 (BCL2-related)

Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

Gene Name: myeloid cell leukemia sequence 1 (BCL2-related)
Synonyms: MCL1, BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Bcl2-L-3, MCL1S, MCL1L, Myeloid cell leukemia ES, MCL 1, MCL1-ES, TM, EAT, Mcl-1
Target Sequences: NM_021960 NP_068779.1 Q07820

Publications (5)

1
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Molecular and cellular biology. 2007 27:4328-39. [PubMed:17371841] [PMC:PMC1900055]
2
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Vogler M, Butterworth M, Majid A, Walewska RJ, Sun XM, Dyer MJ, Cohen GM. Blood. 2009 113:4403-13. (IP) [PubMed:19008458]
3
The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation. Peperzak V, Veraar EA, Keller AM, Xiao Y, Borst J. Journal of immunology (Baltimore, Md. : 1950). 2010 185:6670-8. [PubMed:21048108]
4
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. The Journal of biological chemistry. 2011 286:5921-33. [PubMed:21159778] [PMC:PMC3037705]
5
A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination. Baumgartner CK, Yagita H, Malherbe LP. Journal of immunology (Baltimore, Md. : 1950). 2012 189:2309-17. [PubMed:22844120] [PMC:PMC3424363]
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Filtered by: None
Target
MCL1 / MCL 1 (142)
Reactivity
Human (129)
Mouse (65)
Rat (35)
Bovine (1)
Dog (4)
Guinea pig (2)
Hamster (1)
Horse (2)
Monkey (6)
Pig (4)
Rabbit (4)
Application
IHC (82)
IHC-Fr (3)
IHC-P (26)
WB (133)
Flo (15)
ELISA (44)
ICC (5)
IF (35)
IP (9)
Peptide-ELISA (5)
Host
rabbit (107)
mouse (33)
goat (2)
Isotype
IgG (56)
IgG1 (15)
IgG1,k (3)
IgG2a (11)
IgG2b (2)
Clonality
monoclonal mc (34)
polyclonal pc (108)
Clone
10C5 (2)
2.00E+11 (1)
22 (1)
2E11 (1)
8C6D4B1 (2)
GF1 (1)
MCL.C9 (1)
OTI10D10 (2)
OTI10F6 (2)
OTI2D6 (2)
OTI3A12 (2)
OTI3B4 (2)
OTI4B7 (2)
OTI9C9 (2)
OTI9D7 (2)
RC13 (2)
Format
AP Conjugated (4)
APC (2)
APC Conjugated (5)
Atto 390 Conjugated (1)
Atto 488 Conjugated (1)
Atto 565 Conjugated (1)
Atto 594 Conjugated (2)
Atto 633 Conjugated (1)
Atto 655 Conjugated (1)
Atto 680 Conjugated (1)
Atto 700 Conjugated (1)
Azide-free (3)
Biotin Conjugated (8)
Carrier-free (10)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (8)
HRP Conjugated (8)
PE (1)
PE Conjugated (5)
PerCP Conjugated (1)
RPE Conjugated (1)
SA Conjugated (1)
Unconjugated (88)
Epitope
aa191-226 (8)
aa2-307 (8)
aa217-245 (8)
aa6-328 (8)
100-180 aa (2)
C-Terminus (2)
Internal (2)
aa1-327 (2)
aa121-139 (2)
pSer159 (2)
60-140 aa, Internal (1)
Ser121 (1)
Ser155 (1)
aa1-350 (1)
aa106-155 (1)
aa125-174 (1)
aa303-325 (1)
aa339-350 (1)
aa75-125 (1)
aa91-140 (1)
Publications
No (142)
Showing 1-25 of 142 results

IHC-plus™ MCL1 / MCL 1 Antibody (clone 2E11) LS-B10210
Mouse Monoclonal [clone 2E11] (IgG2a) to Human MCL1 / MCL 1
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50µl 0.9mg/ml  $425.00
Anti-MCL1 / MCL 1 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-MCL1 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MCL1.

IHC-plus™ MCL1 / MCL 1 Antibody LS-B586
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Rat, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05mg 1mg/ml  $425.00
Anti-MCL1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
Immunofluorescence of Mcl-1 in Raji cells with Mcl-1 antibody at 10 ug/ml.

MCL1 / MCL 1 Antibody (aa191-226) LS-C322910
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
Flo, IHC, WB
Unconjugated
200µl  $590.00

MCL1 / MCL 1 Antibody (aa191-226, Biotin) LS-C262845
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
ELISA, Flo, IHC, WB
Biotin Conjugated
200µl  $740.00

MCL1 / MCL 1 Antibody (aa191-226, FITC) LS-C262847
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
ELISA, Flo, IHC, WB
FITC Conjugated
200µl  $740.00

MCL1 / MCL 1 Antibody (aa191-226, APC) LS-C262846
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
ELISA, Flo, IHC, WB
APC Conjugated
200µl 0.5mg/ml  $740.00

IHC-plus™ MCL1 / MCL 1 Antibody (clone 8C6D4B1) LS-B1583
Mouse Monoclonal [clone 8C6D4B1] (IgG1) to Human MCL1 / MCL 1
Human
ELISA, IF, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µl 1mg/ml  $425.00
Anti-MCL1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
Confocal immunofluorescence of HepG2 cells using MCL1 mouse monoclonal antibody (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.

MCL1 / MCL 1 Antibody (aa217-245) LS-C164089
Rabbit Polyclonal to Human MCL1 / MCL 1
Human
IHC, IHC-P, WB
Unconjugated
400µl  $325.00
MCL1 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human stomach tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
MCL1 Antibody western blot of Y79 cell line lysates (35 ug/lane). The MCL1 antibody detected the MCL1 protein (arrow).

MCL1 / MCL 1 Antibody (clone OTI10D10) LS-C115040
Mouse Monoclonal [clone OTI10D10] (IgG2a) to Human MCL1 / MCL 1
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 0.95mg/ml  $345.00
IHC of paraffin-embedded Kidney tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded pancreas tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).

MCL1 / MCL 1 Antibody (clone OTI10F6) LS-C115080
Mouse Monoclonal [clone OTI10F6] (IgG1) to Human MCL1 / MCL 1
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100µl 1mg/ml  $345.00
IHC of paraffin-embedded breast tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Kidney tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).

MCL1 / MCL 1 Antibody (clone OTI10F6, Carrier-free) LS-C784591
Mouse Monoclonal [clone OTI10F6] (IgG1) to Human MCL1 / MCL 1
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100µg  $395.00
IHC of paraffin-embedded breast tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Kidney tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).

IHC-plus™ MCL1 / MCL 1 Antibody (aa121-139) LS-B5215
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Human
IHC, IHC-P
Unconjugated
250µl  $425.00
Anti-MCL1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:25.

IHC-plus™ MCL1 / MCL 1 Antibody LS-B3686
Rabbit Polyclonal to Human MCL1 / MCL 1
Rabbit, Dog, Guinea pig, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-MCL1 antibody IHC of human small intestine, myenteric plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Anti-MCL1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

MCL1 / MCL 1 Antibody LS-C475
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Human
ELISA, ICC, WB
Unconjugated
0.1mg 1mg/ml  $365.00
Immunocytochemistry of Mcl-1 in Raji cells with Mcl-1 antibody at 10 ug/ml.
Western blot of Mcl-1 in Raji cell lysates with Mcl-1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.

MCL1 / MCL 1 Antibody (clone MCL.C9) LS-C136789
Mouse Monoclonal [clone MCL.C9] (IgG) to Human MCL1 / MCL 1
Human
ELISA, WB
Unconjugated
100µg  $385.00

IHC-plus™ MCL1 / MCL 1 Antibody (clone 8C6D4B1) LS-B2561
Mouse Monoclonal [clone 8C6D4B1] (IgG1) to Human MCL1 / MCL 1
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-MCL1 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

IHC-plus™ MCL1 / MCL 1 Antibody (clone 10C5) LS-B13959
Mouse Monoclonal [clone 10C5] (IgG1) to Human MCL1 / MCL 1
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl 0.75mg/ml  $425.00
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Anti-MCL1 mouse monoclonal antibody  immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MCL1.

MCL1 / MCL 1 Antibody LS-C497693
Rabbit Monoclonal to Human MCL1 / MCL 1
Mouse, Rat, Human
Flo, IF, IHC, IP, WB
Unconjugated
50µl  $295.00; 100µl  $385.00; 200µl  $560.00
Immunohistochemistry of paraffin-embedded human pancreas using MCL1 antibodyat dilution of 1:100 (40x lens).
Immunohistochemistry of paraffin-embedded human breast using MCL1 antibodyat dilution of 1:100 (40x lens).

MCL1 / MCL 1 Antibody LS-C8942
Mouse Monoclonal (IgG1) to Human MCL1 / MCL 1
Human
ELISA, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
100µg  $605.00

MCL1 / MCL 1 Antibody (aa91-140) LS-C118513
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl 1mg/ml  $265.00; 100µl 1mg/ml  $325.00
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MCL1 Antibody. The picture on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from HUVEC cells, using MCL1 Antibody. The lane on the right is blocked with the synthesized peptide.

MCL1 / MCL 1 Antibody (100-180 aa) LS-C381781
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
ELISA, IF, WB
Unconjugated
50µl 1mg/ml  $235.00; 100µl 1mg/ml  $265.00; 200µl 1mg/ml  $335.00
Western blot of Phospho-Mcl-1 (S159) antibody

MCL1 / MCL 1 Antibody (aa1-327) LS-C8946
Mouse Monoclonal (IgG1,k) to Human MCL1 / MCL 1
Human
IP, WB
Unconjugated
250µl  $425.00; 500µl  $635.00

MCL1 / MCL 1 Antibody (aa75-125) LS-C289444
Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Human
IP, WB
Unconjugated
100µl 0.2mg/ml  $395.00

MCL1 / MCL 1 Antibody (clone OTI3A12) LS-C115033
Mouse Monoclonal [clone OTI3A12] (IgG2a) to Human MCL1 / MCL 1
Human
IF, IHC, IHC-P, WB
Unconjugated
100µl 0.95mg/ml  $345.00
IHC of paraffin-embedded Adenocarcinoma of colon tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
IHC of paraffin-embedded Kidney tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).

MCL1 / MCL 1 Antibody (clone OTI4B7) LS-C115034
Mouse Monoclonal [clone OTI4B7] (IgG1) to Human MCL1 / MCL 1
IF, IHC, IHC-P, WB
Unconjugated
100µl 0.89mg/ml  $345.00
Immunohistochemical staining of paraffin-embedded colon tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
Immunohistochemical staining of paraffin-embedded Kidney tissue using anti-MCL1 mouse monoclonal antibody. (Dilution 1:50).
Showing 1-25 of 142 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).