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Unfortunately, the antibody (ID:41035) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



MCL1 / MCL 1

myeloid cell leukemia sequence 1 (BCL2-related)

Myeloid cell leukimia-1 (Mcl-1) is a member of the Bcl-2 family of proteins that can act to promote cell survival. While the mechanism by which Mcl-1 inhibits apoptosis is not known, it is thought that it may heterodimerize and neutralize pro-apoptotic members of the Bcl-2 family such as Bim or Bak. Mcl-1 was originally identified in differentiating myeloid cells, but has since been shown to be expressed in multiple cell types. Mcl-1 is essential for embryogenesis (5) and for the development and maintenance of B and T lymphocytes in animals. Mcl-1 exists as at least two distinct isoforms designated Mcl-1L and Mcl-1S. In marked contrast to the larger isoform of Mcl-1, overexpression of Mcl-1S promotes cell death.

Gene Name: myeloid cell leukemia sequence 1 (BCL2-related)
Synonyms: MCL1, BCL2L3, Bcl-2-like protein 3, Bcl-2-related protein EAT/mcl1, Bcl2-L-3, MCL1S, MCL1L, Myeloid cell leukemia ES, MCL 1, MCL1-ES, TM, EAT, Mcl-1
Target Sequences: NM_021960 NP_068779.1 Q07820

Publications (6)

1
Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. Zhao Y, Altman BJ, Coloff JL, Herman CE, Jacobs SR, Wieman HL, Wofford JA, Dimascio LN, Ilkayeva O, Kelekar A, Reya T, Rathmell JC. Molecular and cellular biology. 2007 27:4328-39. [PubMed:17371841] [PMC:PMC1900055]
2
Concurrent up-regulation of BCL-XL and BCL2A1 induces approximately 1000-fold resistance to ABT-737 in chronic lymphocytic leukemia. Vogler M, Butterworth M, Majid A, Walewska RJ, Sun XM, Dyer MJ, Cohen GM. Blood. 2009 113:4403-13. (IP) [PubMed:19008458]
3
The Pim kinase pathway contributes to survival signaling in primed CD8+ T cells upon CD27 costimulation. Peperzak V, Veraar EA, Keller AM, Xiao Y, Borst J. Journal of immunology (Baltimore, Md. : 1950). 2010 185:6670-8. [PubMed:21048108]
4
Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. Coloff JL, Mason EF, Altman BJ, Gerriets VA, Liu T, Nichols AN, Zhao Y, Wofford JA, Jacobs SR, Ilkayeva O, Garrison SP, Zambetti GP, Rathmell JC. The Journal of biological chemistry. 2011 286:5921-33. [PubMed:21159778] [PMC:PMC3037705]
5
Hepatitis B virus X protein enhances cisplatin-induced hepatotoxicity via a mechanism involving degradation of Mcl-1. Hu L, Chen L, Li L, Sun H, Yang G, Chang Y, Tu Q, Wu M, Wang H. Journal of virology. 2011 85:3214-28. [PubMed:21228225] [PMC:PMC3067872]
6
A TCR affinity threshold regulates memory CD4 T cell differentiation following vaccination. Baumgartner CK, Yagita H, Malherbe LP. Journal of immunology (Baltimore, Md. : 1950). 2012 189:2309-17. [PubMed:22844120] [PMC:PMC3424363]
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Filtered By: None
Target
mcl1-mcl-1 (104)
Reactivity
Human (96)
Mouse (39)
Rat (16)
Bovine (1)
Dog (4)
Guinea pig (2)
Hamster (1)
Horse (2)
Monkey (5)
Pig (5)
Rabbit (4)
Application
IHC (31)
IHC-Fr (4)
IHC-P (28)
WB (94)
Flo (13)
ELISA (51)
ICC (9)
IF (19)
IP (16)
Host
rabbit (74)
mouse (29)
goat (1)
Isotype
IgG (53)
IgG1 (17)
IgG1,k (4)
IgG2a (5)
IgG2b (1)
Clonality
monoclonal mc (30)
polyclonal pc (74)
Clone
10C5 (1)
10D10 (1)
10F6 (1)
22 (1)
2D6 (1)
2E11 (1)
3A12 (1)
3B4 (1)
4B7 (1)
8C6, 8C6D4B1 (1)
8C6D4B1 (2)
9C9 (1)
9D7 (1)
GF1 (1)
MCL.C9 (1)
RC13 (3)
Format
AP Conjugated (4)
APC Conjugated (3)
Azide-free (3)
Biotin Conjugated (9)
FITC Conjugated (8)
HRP Conjugated (6)
PE Conjugated (4)
Unconjugated (70)
Epitope
aa216-245 (7)
Internal (3)
aa121-139 (3)
aa2-307 (3)
aa6-328 (3)
pSer159 (3)
C-Terminus (2)
aa1-327 (2)
N-Terminus (1)
Ser121 (1)
Ser155 (1)
aa1-350 (1)
aa100-180 (1)
aa106-155 (1)
aa125-174 (1)
aa148-152 (1)
aa191-226 (1)
aa217-245 (1)
aa303-325 (1)
aa339-350 (1)
aa60-140 (1)
aa75-125 (1)
aa91-140 (1)
Publications
No (104)
Showing 1-25 out of 104 results
Anti-MCL1 / MCL 1 Antibody (clone 2E11) IHC-plus™ LS-B10210

Mouse Monoclonal [clone 2E11] (IgG2a) to Human MCL1 / MCL 1
Human
Flo IF IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (C-Terminus) IHC-plus™ LS-B586

Rabbit Polyclonal to Human MCL1 / MCL 1
Mouse, Rat, Human
ICC IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (clone 8C6D4B1) LS-C82153

Mouse Monoclonal [clone 8C6D4B1] (IgG1) to Human MCL1 / MCL 1
Human
ELISA IHC-Fr IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (clone 8C6, 8C6D4B1) IHC-plus™ LS-B1583

Mouse Monoclonal [clone 8C6, 8C6D4B1] (IgG1) to Human MCL1 / MCL 1
Human
ELISA IHC-Fr IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (clone 10D10) LS-C115040

Mouse Monoclonal [clone 10D10] (IgG2a) to Human MCL1 / MCL 1
Human
Flo IF IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (aa121-139) IHC-plus™ LS-B5215

Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Human
IHC-P
Unconjugated
Anti-MCL1 / MCL 1 Antibody (FITC) LS-C262847

Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
ELISA Flo IHC WB
FITC Conjugated
Anti-MCL1 / MCL 1 Antibody (APC) LS-C262846

Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Human
ELISA Flo IHC WB
APC Conjugated
Anti-MCL1 / MCL 1 Antibody IHC-plus™ LS-B3686

Rabbit Polyclonal to Human MCL1 / MCL 1
Rabbit, Dog, Guinea pig, Pig, Human, Monkey
IF IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (clone MCL.C9) LS-C136789

Mouse Monoclonal [clone MCL.C9] (IgG) to Human MCL1 / MCL 1
Human
ELISA WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (clone RC13, Biotin) LS-C88367

Mouse Monoclonal [clone RC13] (IgG1,k) to Human MCL1 / MCL 1
Human
IHC-P IP WB
Biotin Conjugated
Anti-MCL1 / MCL 1 Antibody (clone 10F6) LS-C115080

Mouse Monoclonal [clone 10F6] (IgG1) to Human MCL1 / MCL 1
Human
Flo IF IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (clone 8C6D4B1) IHC-plus™ LS-B2561

Mouse Monoclonal [clone 8C6D4B1] (IgG1) to Human MCL1 / MCL 1
Human
ELISA IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (clone 10C5) IHC-plus™ LS-B13959

Mouse Monoclonal [clone 10C5] (IgG1) to Human MCL1 / MCL 1
Human
IF IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody LS-C497693

Rabbit Monoclonal to Human MCL1 / MCL 1
Human
Flo IF IHC IP WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody LS-C8942

Mouse Monoclonal (IgG1) to Human MCL1 / MCL 1
Human
ELISA IHC-Fr IHC-P IP WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (aa91-140) LS-C118513

Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Rat, Human
ELISA IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (Internal) LS-C475

Rabbit Polyclonal to Human MCL1 / MCL 1
Human
ICC WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (aa1-327) LS-C8946

Mouse Monoclonal (IgG1,k) to Human MCL1 / MCL 1
Human
IP WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (aa217-245) LS-C164089

Rabbit Polyclonal to Human MCL1 / MCL 1
Human
IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody LS-C500088

Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Human
ELISA IF IHC WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (clone GF1) LS-C190303

Mouse Monoclonal [clone GF1] (IgG1) to Human MCL1 / MCL 1
Human
ELISA IF IHC WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody LS-C408815

Rabbit Polyclonal (IgG) to Human MCL1 / MCL 1
Mouse, Rat, Human
Flo ICC IHC IP WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (clone 9C9) LS-C115037

Mouse Monoclonal [clone 9C9] (IgG2b) to Human MCL1 / MCL 1
Human
IF IHC-P WB
Unconjugated
Anti-MCL1 / MCL 1 Antibody (clone 9D7) LS-C115035

Mouse Monoclonal [clone 9D7] (IgG2a) to Human MCL1 / MCL 1
Human
IF IHC-P WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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