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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MCAM / CD146

melanoma cell adhesion molecule

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.

Gene Name: melanoma cell adhesion molecule
Family/Subfamily: Immunoglobulin , not assigned-Immunoglobulin
Synonyms: MCAM, CD146, CD146 antigen, Gicerin, Melanoma adhesion molecule, MUC18, p1h12
Target Sequences: NM_006500 NP_006491.2 P43121

Publications (1)

1
Melanoma Cell Galectin-1 Ligands Functionally Correlate with Malignant Potential. Yazawa EM, Geddes-Sweeney JE, Cedeno-Laurent F, Walley KC, Barthel SR, Opperman MJ, Liang J, Lin JY, Schatton T, Laga AC, Mihm MC, Qureshi AA, Widlund HR, Murphy GF, Dimitroff CJ. The Journal of investigative dermatology. 2015 135:1849-1862. (WB; Human) [Full Text Article] [PubMed:25756799] [PMC:PMC4466041] Related Antibodies: LS-B4050.

Filtered by: None
Target
MCAM / CD146 (170)
Reactivity
Human (141)
Mouse (33)
Rat (19)
Bovine (4)
Canine (2)
Chicken (8)
Chimpanzee (6)
Dog (11)
Gibbon (3)
Horse (8)
Orangutan (3)
Pig (8)
Rabbit (21)
Application
IHC (88)
IHC-Fr (18)
IHC-P (45)
WB (104)
Flo (67)
ELISA (52)
ICC (13)
IF (23)
IP (23)
Peptide-ELISA (1)
Host
rabbit (81)
mouse (87)
goat (1)
sheep (1)
Isotype
IgG (32)
IgG1 (47)
IgG1,k (19)
IgG2a (1)
IgG2a,k (1)
IgG2b (8)
IgG2b,k (4)
Clonality
monoclonal mc (86)
polyclonal pc (82)
recombinant monoclonal rmc (2)
Clone
6C3E6 (1)
6C3F1 (1)
BSB-122 (2)
C146/634 (3)
C264 (4)
CDLA146 (3)
COM 7A4 (1)
MCAM/1101 (3)
MUC18/1130 (3)
OJ79c (7)
OJ79C (2)
OTI1F10 (2)
OTI2B2 (2)
OTI2G10 (2)
OTI3D1 (2)
OTI5C4 (2)
P1H12 (4)
rMUC18/1130 (2)
SHM-57 (1)
SPM620 (2)
UMAB154 (2)
UMAB155 (2)
Format
AP Conjugated (4)
APC (3)
APC Conjugated (9)
Azide-free (9)
Biotin Conjugated (15)
Carrier-free (8)
Concentrated (2)
Cy3 Conjugated (3)
Cy7 Conjugated (3)
FITC Conjugated (19)
HRP Conjugated (10)
PE Conjugated (13)
Preservative Free (1)
Ready-to-Use (5)
Unconjugated (94)
Epitope
aa224-464 (8)
aa323-560 (8)
aa324-565 (8)
aa532-558 (8)
aa289-338 (4)
aa533-582 (4)
Internal (2)
aa84-189 (2)
C-Terminus (1)
Extracellular Domain (1)
Tyr641 (1)
aa161-189 (1)
aa19-560 (1)
aa433-647 (1)
aa584-600 (1)
aa59-401 (1)
aa596-646 (1)
aa600-650 (1)
internal region (1)
Publications
No (169)
Yes (1)
Showing 1-25 of 170 results

PathPlus™ MCAM / CD146 Antibody (aa84-189, clone 6C3E6) LS-B10746
Mouse Monoclonal [clone 6C3E6] (IgG1) to Human MCAM / CD146
Human
ELISA, Flo, IHC, IHC-P, WB
Unconjugated
100µg 1mg/ml  $425.00
Anti-MCAM / CD146 antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot using MCAM monoclonal antibody against human MCAM recombinant protein. (Expected MW is 37.7 kDa)

IHC-plus™ MCAM / CD146 Antibody (clone P1H12) LS-B4050
Publications (1)
Publications (1)
Mouse Monoclonal [clone P1H12] (IgG1) to Human MCAM / CD146
Human
Flo, IHC, IHC-Fr, IHC-P, IP, WB
Unconjugated
50µg 0.5mg/ml  $425.00
Anti-MCAM / CD146 antibody IHC of human vessels in human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.
Staining of HUVECs with 0.125 ug of Purified Mouse IgG1, K isotype control (blue) or 0.125 ug of Purified anti-human CD146 (Muc 18, MCAM, Mel-CAM, EndoCAM) (purple) followed by PE Donkey F(ab')2 Fragment Anti-Mouse IgG (H+L, Minimal Reactivity to Rat IgG). Total viable cells were used for analysis.

IHC-plus™ MCAM / CD146 Antibody (Tyr641) LS-B3628
Rabbit Polyclonal to Human MCAM / CD146
Human
IHC, IHC-P, WB
Unconjugated
50µg 0.25mg/ml  $425.00
Anti-MCAM / CD146 antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

IHC-plus™ MCAM / CD146 Antibody (aa289-338) LS-B11486
Rabbit Polyclonal to Human MCAM / CD146
Rabbit, Bovine, Pig, Horse, Human
IHC, IHC-P, WB
Unconjugated
100µl  $485.00
Anti-MCAM / CD146 antibody IHC staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
MCAM / CD146 antibody Western blot of HepG2 Cell lysate. Antibody concentration 1 ug/ml. This image was taken for the unconjugated form of this product. Other forms have not been tested.

MCAM / CD146 Antibody (aa19-560) LS-C35841
Mouse Monoclonal (IgG2a) to Rat MCAM / CD146
Rat
ELISA, Flo, WB
Unconjugated
100µg  $650.00

MCAM / CD146 Antibody (aa161-189) LS-C164076
Rabbit Polyclonal to Human MCAM / CD146
Human
Flo, IHC, IHC-P, WB
Unconjugated
400µl  $325.00
Formalin-fixed and paraffin-embedded human skin reacted with MCAM Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Western blot of MCAM Antibody in A2058 cell line lysates (35 ug/lane). MCAM (arrow) was detected using the purified antibody.(2 ug/ml)

MCAM / CD146 Antibody (aa433-647) LS-C33782
Rabbit Polyclonal to Human MCAM / CD146
Human
IHC
Unconjugated
50µg 0.2mg/ml  $315.00
Angioscarcoma stained with anti-CD146

MCAM / CD146 Antibody (aa532-558, PE) LS-C262812
Rabbit Polyclonal (IgG) to Human MCAM / CD146
Human
ELISA, IHC, WB
PE Conjugated
200µl  $740.00

PathPlus™ MCAM / CD146 Antibody (aa84-189, clone 6C3F1) LS-B14157
Mouse Monoclonal [clone 6C3F1] (IgG1) to Human MCAM / CD146
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100µg 1mg/ml  $425.00
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Western blot using MCAM monoclonal antibody against human MCAM recombinant protein. (Expected MW is 37.7 kDa)

MCAM / CD146 Antibody LS-C675304
Rabbit Monoclonal (IgG) to Human MCAM / CD146
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
50µl  $315.00; 100µl  $425.00
Immunohistochemistry Dilution at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal Goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated Secondary antibody and visualized using an HRP conjugated SP system.
Immunofluorescence staining of U251 cells diluted at 1:37,counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C.The Secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG (H+L).

MCAM / CD146 Antibody LS-C484185
Rabbit Polyclonal to Human MCAM / CD146
Human
ELISA, Flo, ICC, IF, IHC, IHC-P
Unconjugated
50µl  $275.00; 100µl  $355.00

MCAM / CD146 Antibody (Biotin) LS-C14263
Mouse Monoclonal (IgG1) to Human MCAM / CD146
Rabbit, Mouse, Dog, Human
ELISA, Flo, ICC, IHC, IP
Biotin Conjugated
100µg  $680.00

MCAM / CD146 Antibody (Azide-free) LS-C14275
Mouse Monoclonal (IgG1) to Human MCAM / CD146
Human
ELISA, Flo, IHC, IHC-Fr
Unconjugated, Azide-free
1mg  $875.00

MCAM / CD146 Antibody (clone OTI5C4) LS-C338783
Mouse Monoclonal [clone OTI5C4] (IgG1) to Human MCAM / CD146
Human
IHC, IHC-P, WB
Unconjugated
100µl  $345.00
IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-MCAM mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120°C for 3min).
IHC of paraffin-embedded Human Kidney tissue using anti-MCAM mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH9.0, 120°C for 3min).

MCAM / CD146 Antibody (clone P1H12, PE) LS-C742346
Mouse Monoclonal [clone P1H12] (IgG1) to Human MCAM / CD146
Rabbit, Mouse, Canine, Human
Flo, ICC, IHC-Fr, IHC-P, IP, WB
PE Conjugated
100tst  $315.00

MCAM / CD146 Antibody (FITC) LS-C152896
Mouse Monoclonal (IgG1) to Human MCAM / CD146
Rabbit, Mouse, Dog, Human
Flo, IHC, IHC-Fr
FITC Conjugated
100µg 1mg/ml  $590.00

MCAM / CD146 Antibody (aa584-600) LS-C312887
Rabbit Polyclonal to Human MCAM / CD146
Human
IHC, IHC-P, WB
Unconjugated
100µg 200µl 0.5mg/ml  $305.00
MCAM / CD146 antibody. IHC(P): Human Intestinal Cancer Tissue.
WB of MCAM / CD146 antibody. All lanes: Anti-MCAM at 0.5ug/ml. Lane 1: A549 Whole Cell Lysate at 40ug. Lane 2: A549 Whole Cell Lysate at 40ug. Lane 3: HELA Whole Cell Lysate at 40ug. Lane 4: SW620 Whole Cell Lysate at 40ug. Predicted bind size: 72KD. Observed bind size: 72KD.

MCAM / CD146 Antibody LS-C658485
Rabbit Monoclonal (IgG) to Human MCAM / CD146
Human
IHC, WB
Unconjugated
50µl  $445.00

MCAM / CD146 Antibody (Extracellular Domain) LS-C130676
Sheep Polyclonal (IgG) to Mouse MCAM / CD146
Mouse
ELISA, WB
Unconjugated
100µg  $770.00

MCAM / CD146 Antibody (aa224-464) LS-C295341
Rabbit Polyclonal to Mouse MCAM / CD146
Mouse
WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $255.00; 200µl 0.5mg/ml  $295.00; 1ml 0.5mg/ml  $515.00
Western blot of recombinant MCAM / CD146.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MCAM / CD146 Antibody (clone MUC18/1130) LS-C390627
Mouse Monoclonal [clone MUC18/1130] (IgG1,k) to Human MCAM / CD146
Human
Flo, IF, IHC, IHC-P
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00
Formalin-fixed, paraffin-embedded human tonsil stained with CD146 antibody (MUC18/1130).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human melanoma stained with CD146 antibody (MUC18/1130).  This image was taken for the unmodified form of this product. Other forms have not been tested.

MCAM / CD146 Antibody (clone MUC18/1130, Ready-to-Use) LS-C390635
Mouse Monoclonal [clone MUC18/1130] (IgG1,k) to Human MCAM / CD146
Human
Flo, IF, IHC, IHC-P
Unconjugated, Ready-to-Use
7ml  $465.00
Formalin-fixed, paraffin-embedded human tonsil stained with CD146 antibody (MUC18/1130).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human melanoma stained with CD146 antibody (MUC18/1130).  This image was taken for the unmodified form of this product. Other forms have not been tested.

MCAM / CD146 Antibody (clone MUC18/1130, Azide-free) LS-C390626
Mouse Monoclonal [clone MUC18/1130] (IgG1,k) to Human MCAM / CD146
Human
Flo, IF, IHC, IHC-P
Unconjugated, Azide-free
100µg 1mg/ml  $465.00
Formalin-fixed, paraffin-embedded human tonsil stained with CD146 antibody (MUC18/1130).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Formalin-fixed, paraffin-embedded human melanoma stained with CD146 antibody (MUC18/1130).  This image was taken for the unmodified form of this product. Other forms have not been tested.

IHC-plus™ MCAM / CD146 Antibody LS-B13027
Rabbit Polyclonal (IgG) to Human MCAM / CD146
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µg  $425.00
Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.

MCAM / CD146 Antibody (clone SPM620) LS-C390616
Mouse Monoclonal [clone SPM620] (IgG1,k) to Human MCAM / CD146
Human
Flo, IF, IHC, IHC-P
Unconjugated
20µg 0.2mg/ml  $295.00; 100µg 0.2mg/ml  $465.00
Formalin-fixed, paraffin-embedded human melanoma stained with anti-CD146 antibody (SPM620).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Showing 1-25 of 170 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).