MC1R

melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

MC1R (4)

Publications

No (4)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human MC1R Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G59192

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MC1R Protein (Recombinant GST) (Full Length) - LS-G29283

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

61.1 kDa

Price:

2 µg/$439

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Human MC1R Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77264

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.5 kDa

Price:

20 µg/$150

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MC1R Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99736

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

34.5 kDa

Price:

100 µg/$494

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