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MBTPS1 / S1P

membrane-bound transcription factor peptidase, site 1

Serine protease that catalyzes the first step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs). Other known substrates are BDNF, GNPTAB and ATF6. Cleaves after hydrophobic or small residues, provided that Arg or Lys is in position P4. Cleaves known substrates after Arg-Ser-Val-Leu (SERBP-2), Arg-His-Leu-Leu (ATF6), Arg-Gly-Leu-Thr (BDNF) and its own propeptide after Arg-Arg-Leu-Leu. Mediates the protein cleavage of GNPTAB into subunit alpha and beta, thereby participating in biogenesis of lysosomes.

Gene Name: membrane-bound transcription factor peptidase, site 1
Family/Subfamily: Exopeptidase , Serine S8
Synonyms: MBTPS1, Endopeptidase S1P, PCSK8, KIAA0091, Site-1 protease, Subtilisin/kexin isozyme-1, S1P, SKI-1, SKI1, Subtilisin/kexin-isozyme 1
Target Sequences: NM_003791 NP_003782.1 Q14703

☰ Filters
Products
Antibodies (14)
Primary (14)
MBTPS1 / S1P (14)
Human (14)
Mouse (5)
Rat (5)
IHC (4)
IHC-P (3)
WB (6)
ELISA (10)
IF (7)
Peptide-ELISA (1)
rabbit (8)
mouse (6)
Product Group
IHCPlus (1)
IgG (7)
IgG1,k (6)
monoclonal mc (6)
polyclonal pc (8)
APC Conjugated (1)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
PE Conjugated (1)
Unconjugated (9)
180-260 aa, C-terminal (1)
aa246-355 (1)
No (14)
MBTPS1 / S1P Antibody - Human Colon: Formalin-Fixed, Paraffin-Embedded (FFPE)
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MBTPS1 / S1P Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MBTPS1 / S1P Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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MBTPS1 / S1P Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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MBTPS1 / S1P Mouse anti-Human Monoclonal (aa246-355) Antibody
Human
ELISA, IF
Unconjugated
100 µg/$705
Select
MBTPS1 / S1P Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
100 µl/$904
Select
MBTPS1 / S1P Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, IF
Biotin Conjugated
100 µl/$904
Select
MBTPS1 / S1P Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, IF
FITC Conjugated
100 µl/$904
Select
MBTPS1 / S1P Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, IF
APC Conjugated
100 µl/$904
Select
MBTPS1 / S1P Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, IF
PE Conjugated
100 µl/$904
Select
MBTPS1 / S1P Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
MBTPS1 / S1P Antibody - Immunohistochemistry of paraffin-embedded human lung tissue at dilution 1:100
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MBTPS1 / S1P Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
MBTPS1 / S1P Antibody - Immunohistochemistry of paraffin-embedded human lung tissue at dilution 1:100
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MBTPS1 / S1P Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µl/$294; 100 µl/$360
Select
MBTPS1 / S1P Rabbit anti-Human Polyclonal (180-260 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
MBTPS1 / S1P Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
Select
MBTPS1 / S1P Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$386
Viewing 1-14 of 14 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).