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MBNL2

muscleblind-like splicing regulator 2

Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM).

Gene Name: muscleblind-like splicing regulator 2
Synonyms: MBNL2, MBLL, MBLL39, MLP1, Muscleblind-like protein 2, Muscleblind-like protein 1, Muscleblind-like protein-like, RP11-128N14.1, Muscleblind-like 2, PRO2032
Target Sequences: AF061261 AAC67242.1 Q5VZF2

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Proteins (7)
Over-Expression Lysate (4)
Recombinant (3)
MBNL2 (7)
No (7)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (5)
Human (5)
293T Cells (2)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (1)
MBNL2 Protein - 12.5% SDS-PAGE of human MBNL2 stained with Coomassie Blue
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Wheat Germ Extract
GST
66.9 kDa
2 µg/$439
MBNL2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MBNL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.2 kDa
20 µg/$150
MBNL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
39.2 kDa
20 µg/$150
MBNL2 Protein - Purified recombinant protein MBNL2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
39.2 kDa
20 µg/$1,107
MBNL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.2 kDa
100 µg/$494
MBNL2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
39.2 kDa
100 µg/$494
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).