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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Infectious Disease
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MBD2

methyl-CpG binding domain protein 2

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene.

Gene Name: methyl-CpG binding domain protein 2
Synonyms: MBD2, Demethylase, DMTase, NY-CO-41
Target Sequences: NM_003927 NP_003918.1 Q9UBB5


MBD2 Antibody - Anti-MBD2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.
Select
Goat Polyclonal to Human MBD2
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
MBD2 Antibody - Anti-MBD2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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Rabbit Polyclonal to Human MBD2
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $425.00
MBD2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human MBD2
Mouse, Human
IHC, IHC-P, IP, WB
Unconjugated
50µl   0.2mg/ml   $425.00
MBD2 Antibody
Select
Rabbit Polyclonal (IgG) to Human MBD2
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $265.00
MBD2 Antibody - Fluorescent confocal image of HeLa cell stained with MBD2 Antibody. HeLa cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with MBD2 primary antibody (1:25, 1 h at 37°C). For secondary antibody, Alexa Fluor 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37°C). Cytoplasmic actin was counterstained with Alexa Fluor 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37°C). Nuclei were counterstained with DAPI (blue) (10 ug/ml, 10 min). MBD2 immunoreactivity is localized to Nucleus significantly.
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Rabbit Polyclonal to Human MBD2
Human
IF, WB
Unconjugated
400µl   $325.00
MBD2 Antibody - The anti-MBD2 N-term Antibody is used in Western blot to detect MBD2 in A375 cell lysate (lane 1) and mouse brain tissue lysate (lane 2) lysate.
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Rabbit Polyclonal to Human MBD2
Mouse, Human
WB
Unconjugated
400µl   $325.00
MBD2 Antibody - A: Marker, B: HepG2 Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
Rabbit Polyclonal (IgG) to Human MBD2
Chicken, Bovine, Rat, Pig, Horse, Bat, Rabbit, Mouse, Guinea pig, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $325.00
MBD2 Antibody - MBD2 antibody Western blot of 721_B cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human MBD2
Mouse, Rat, Bat, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
Select
Rabbit Polyclonal to Human MBD2
Human
ELISA, IHC, IP, WB
Unconjugated
50µg   $285.00; 100µg   1mg/ml   $355.00
MBD2 Antibody - MBD2 Antibody staining MBD2 in human colon tissue sections by Immunohistochemistry (IHC-P - paraformaldehyde-fixed, paraffin-embedded sections). Tissue was fixed with formaldehyde and blocked with 3% BSA for 0. 5 hour at room temperature; antigen retrieval was by heat mediation with a citrate buffer (pH6). Samples were incubated with primary antibody (1/25) for 1 hours at 37°C. A undiluted biotinylated goat polyvalent antibody was used as the secondary antibody.
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Mouse Monoclonal [clone 1812CT625.9.45] (IgG1,k) to Human MBD2
Human
ELISA, IHC-P, WB
Unconjugated
200µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Mouse, Rat, Human
IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Human
ELISA, WB
Unconjugated
100µg   $375.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Mouse, Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Mouse, Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Mouse, Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Mouse, Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Mouse, Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Mouse, Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MBD2
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
MBD2 Antibody - Western blot analysis of MBD2 using K562 whole cells lysates
Select
Rabbit Polyclonal (IgG) to Human MBD2
Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Viewing 1-25 of 51 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).