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MATK
megakaryocyte-associated tyrosine kinase
MATK has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene.
| Gene Name: | megakaryocyte-associated tyrosine kinase |
| Family/Subfamily: | Protein Kinase , Csk |
| Synonyms: | MATK, Batk, CTK, Csk-homologous kinase, Hydroxyaryl-protein kinase, HYL, HYL tyrosine kinase, LSK, HHYLTK, Protein kinase HYL, Ntk, Tyrosine-protein kinase CTK, Tyrosylprotein kinase, Tyrosine kinase MATK, CHK, CSK homologous kinase, HYLTK |
| Target Sequences: | NM_002378 NP_002369.2 P42679 |
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