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MAS1 / MAS

MAS1 oncogene

Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1.

Gene Name:	MAS1 oncogene
Family/Subfamily:	GPCR , Orphan-A
Synonyms:	MAS1, Mas proto-oncogene, Proto-oncogene Mas, MAS, MAS1 oncogene
Target Sequences:	NM_002377 NP_002368.1 P04201

Publications (3)

Changes in the renin angiotensin system during the development of colorectal cancer liver metastases. Neo JH, Ager EI, Angus PW, Zhu J, Herath CB, Christophi C. BMC cancer. 2010 10:134. (IHC-P; Mouse) [Full Text Article] [PubMed:20380732] [PMC:PMC2860361] Related Antibodies: LS-A1528.

Expression and function of the ACE2/angiotensin(1-7)/Mas axis in osteosarcoma cell lines U-2 OS and MNNG-HOS. Ender SA, Dallmer A, Lässig F, Lendeckel U, Wolke C. Molecular medicine reports. 2014 August;10:804-10. (Human) [Full Text Article] [PubMed:24858078] Related Antibodies: LS-B3564.

Mitochondrial assembly receptor expression is an independent prognosticator for patients with oral tongue squamous cell carcinoma. Su YY, Chen CH, Chien CY, Lin WC, Huang WT, Li SH. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2017 July;18:1470320317717904. (Human) [Full Text Article] [PubMed:28747140] [PMC:PMC5843911] Related Antibodies: LS-A1528.

MAS1 / MAS Protein - 12.5% SDS-PAGE of human MAS1 stained with Coomassie Blue

Human MAS1 / MAS Protein (Recombinant GST) (Full Length) - LS-G29274

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

63.9 kDa

Price:

2 µg/$439

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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