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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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Cell Cycle Pathways
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MARK2

MAP/microtubule affinity-regulating kinase 2

Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4, MAPT/TAU, and RAB11FIP2. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.

Gene Name: MAP/microtubule affinity-regulating kinase 2
Family/Subfamily: Protein Kinase , MARK
Synonyms: MARK2, ELKL motif kinase 1, EMK-1, ELKL motif kinase, EMK1, PAR-1, PAR1 homolog, Par1b, Par-1b, Ser/Thr protein kinase PAR-1B, Emk, PAR1 homolog b
Target Sequences: NM_017490 NP_059672.2 Q7KZI7

Viewing 1-25 of 43 items
MARK2 Antibody - Anti-MARK2 antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
MARK2 Antibody - Anti-MARK2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50µl   1mg/ml   $425.00
MARK2 Antibody - Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $425.00
MARK2 Antibody - Immunohistochemical analysis of MARK2 staining in human prostate cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
Rabbit Polyclonal to Human MARK2
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100µl   1mg/ml   $245.00
MARK2 Antibody - Immunohistochemical analysis of MARK2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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Rabbit Polyclonal to Human MARK2
Mouse, Rat, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30µl   1mg/ml   $205.00; 100µl   1mg/ml   $245.00; 200µl   1mg/ml   $305.00
MARK2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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Rabbit Polyclonal to Human MARK2
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400µl   $325.00
MARK2 Antibody - Western Blot of Rabbit anti-MARK2pT595 antibody. Lane 1: wild type Jurkat cells. Lane 2: wild type Jurkat cells stimulated with CD3/CD28 (T-cell receptor stimulation). Load: 35 µg per lane. Primary antibody: MARK2 pT595 antibody at 1:500 for overnight at 4°C. Secondary antibody: IRDye800™ rabbit secondary antibody at 1:10,000 for 45 min at RT.
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Rabbit Polyclonal to Human MARK2
ELISA, WB
Unconjugated
100µg   1mg/ml   $425.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Human
ELISA, IHC, IP, WB
Unconjugated
100µg   $335.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
MARK2 Antibody
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
MARK2 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using MARK2 antibody.
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Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human
ELISA, IF, IHC
Unconjugated
100µg   $305.00
MARK2 Antibody - Western blot of MARK2 antibody
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Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human, Monkey
ELISA, IF, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
MARK2 Antibody - Peptide - + Immunofluorescence analysis of A549 cells, using MARK2 antibody.
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Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µg   $305.00
MARK2 Antibody - MARK2 monoclonal antibody (M01), clone 3B12. Western Blot analysis of MARK2 expression in PC-12.
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Mouse Monoclonal [clone 3B12] (IgG2a,k) to Human MARK2
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   $365.00
MARK2 Antibody - Immunohistochemistry image of paraffin-embedded human kidney tissue at a dilution of 1:100
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Rabbit Polyclonal (IgG) to Human MARK2
Human
ELISA, IHC, IHC-P
Unconjugated
50µg   $285.00; 100µg   $385.00
MARK2 Antibody - Western blot analysis of extracts of Mouse brain cell lines.
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Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human
IHC, IP, WB
Unconjugated
50µl   $305.00; 100µl   $345.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human
ELISA, IF
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Human
ELISA, IHC, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MARK2
Mouse, Rat, Human
IF, Peptide-ELISA
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00

Viewing 1-25 of 43 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).