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MARCO

macrophage receptor with collagenous structure

MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains.

Gene Name: macrophage receptor with collagenous structure
Synonyms: MARCO, Macrophage receptor MARCO, Macrophage receptors marco, SCARA2
Target Sequences: NM_006770 NP_006761.1 Q9UEW3

Publications (1)

1
Lipid-loaded tumor-associated macrophages sustain tumor growth and invasiveness in prostate cancer. Michela Masetti , Roberta Carriero , Federica Portale, Giulia Marelli, Nicolò Morina, Marta Pandini, Marta Iovino, Bianca Partini, Marco Erreni, Andrea Ponzetta, Elena Magrini, Piergiuseppe Colombo, Grazia Elefante, Federico Simone Colombo, Joke M M den Haan, Clelia Peano, Javier Cibella, Alberto Termanini, Paolo Kunderfranco, Jolanda Brummelman, Matthew Wai Heng Chung, Massimo Lazzeri, Rodolfo Hurle, Paolo Casale, Enrico Lugli, Ronald A DePinho, Subhankar Mukhopadhyay, Siamon Gordon, Diletta Di. The Journal of experimental medicine. 2022 Feburary;219: [Full Text Article] [PubMed:34919143] [PMC:PMC8932635] Related Antibodies: LS-B15577.

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Products
Proteins (6)
Over-Expression Lysate (2)
Recombinant (4)
MARCO (6)
No (6)
8His, N-terminus (1)
His,N-terminus (1)
His-T7 (2)
Myc-DDK (Flag) (2)
Human (1)
Mouse (3)
Rat (1)
293T Cells (1)
E. coli (2)
HEK 293 Cells (1)
Mammalian Cells (2)
Purified (1)
Low endotoxin level (2)
MARCO Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52.5 kDa
20 µg/$150
MARCO Protein - Recombinant Macrophage Receptor With Collagenous Structure By SDS-PAGE
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E. coli
His-T7
19.6 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
MARCO Protein - Recombinant Macrophage Receptor With Collagenous Structure By SDS-PAGE
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E. coli
His-T7
20.0 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
Select
Mammalian Cells
8His, N-terminus
Less than 0.1 ng/mL (Less than 1 EU/µg) (determined by LAL method).
10 µg/$269; 50 µg/$372; 500 µg/$1,245; 1 mg/$1,627
Select
Mammalian Cells
His,N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
46.2 kDa
10 µg/$269; 50 µg/$368
MARCO Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
52.5 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).