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MARCH6 / DOA10
membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
E3 ubiquitin-protein ligase that promotes ubiquitination of DIO2, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1.
| Gene Name: | membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase |
| Synonyms: | MARCH6, DOA10, Doa10 homolog, KIAA0597, RING finger protein 176, TEB4, MARCH-VI, Protein TEB-4, RNF176 |
| Target Sequences: | NM_005885 NP_005876.2 O60337 |
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