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MARCH5

membrane-associated ring finger (C3HC4) 5

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.

Gene Name: membrane-associated ring finger (C3HC4) 5
Synonyms: MARCH5, MARCH-V, RING finger protein 153, RNF153, Mitochondrial ubiquitin ligase, MITOL
Target Sequences: NM_017824 NP_060294.1 Q9NX47

Publications (1)

1
Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling. Alban Ordureau, Joao A Paulo, Jiuchun Zhang, Heeseon An, Kirby N Swatek, Joe R Cannon, Qiaoqiao Wan, David Komander, J Wade Harper. Molecular cell. 2020 Mar;77:1124-1142e10. [Full Text Article] [PubMed:32142685] [PMC:PMC7098486] Related Antibodies: LS-C358404.

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Products
Proteins (4)
Over-Expression Lysate (2)
Recombinant (2)
MARCH5 (4)
No (4)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (3)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
MARCH5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
31.1 kDa
100 µg/$494
MARCH5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
31.1 kDa
20 µg/$150
MARCH5 Protein - 12.5% SDS-PAGE of human MARCH5 stained with Coomassie Blue
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Wheat Germ Extract
GST
57.6 kDa
10 µg/$479; 25 µg/$670
MARCH5 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).