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E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system.
Gene Name: | membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase |
Synonyms: | MARCH1, MARCH-I, RING finger protein 171, RNF171 |
Target Sequences: | NM_017923 NP_060393.1 Q8TCQ1 |
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