MAPKAPK5 / PRAK

mitogen-activated protein kinase-activated protein kinase 5

Tumor suppressor serine/threonine-protein kinase involved in mTORC1 signaling and post-transcriptional regulation. Phosphorylates FOXO3, ERK3/MAPK6, ERK4/MAPK4, HSP27/HSPB1, p53/TP53 and RHEB. Acts as a tumor suppressor by mediating Ras-induced senescence and phosphorylating p53/TP53. Involved in post-transcriptional regulation of MYC by mediating phosphorylation of FOXO3: phosphorylation of FOXO3 leads to promote nuclear localization of FOXO3, enabling expression of miR-34b and miR-34c, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent MYC translation. Acts as a negative regulator of mTORC1 signaling by mediating phosphorylation and inhibition of RHEB. Part of the atypical MAPK signaling via its interaction with ERK3/MAPK6 or ERK4/MAPK4: the precise role of the complex formed with ERK3/MAPK6 or ERK4/MAPK4 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPK (ERK3/MAPK6 or ERK4/MAPK4), ERK3/MAPK6 (or ERK4/MAPK4) is phosphorylated and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6 (or ERK4/MAPK4). Mediates phosphorylation of HSP27/HSPB1 in response to PKA/PRKACA stimulation, inducing F-actin rearrangement.

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Products

Antibodies (72)

Proteins (4)

ELISA Kits (2)

Type

Cell-Based (1)

Cell-Based Phosphorylation (1)

Primary (72)

Recombinant (4)

Target

MAPKAPK5 / PRAK (78)

Reactivity

Human (74)

Mouse (24)

Rat (2)

Bovine (2)

Chicken (1)

Dog (2)

Guinea pig (2)

Horse (2)

Monkey (2)

Pig (2)

Rabbit (2)

Zebrafish (1)

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Application

IHC (20)

IHC-P (6)

WB (66)

ELISA (30)

ICC (1)

IF (1)

IP (5)

Peptide-ELISA (6)

Host

rabbit (41)

mouse (29)

goat (2)

Product Group

IHCPlus (2)

Isotype

IgG (36)

IgG1 (6)

IgG1,k (6)

IgG2a (10)

IgG2b (6)

Clonality

monoclonal mc (28)

polyclonal pc (44)

Clone

7H10B4 (1)

OTI1A12 (2)

OTI1A7 (2)

OTI1B3 (2)

OTI1B4 (2)

OTI1D11 (2)

OTI1F5 (2)

OTI1H3 (2)

OTI4G4 (2)

OTI4H4 (2)

OTI5E1 (2)

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Format

96-Well Microplate (2)

APC Conjugated (4)

Azide-free (2)

Biotin Conjugated (5)

Carrier-free (10)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (4)

Unconjugated (49)

Epitope

aa197-471 (20)

Thr182 (7)

pSer93 (7)

pThr182 (5)

120-200 aa (2)

aa148-197 (1)

aa171-220 (1)

aa192-206 (1)

aa197-457 (1)

aa306-318 (1)

aa371-471 (1)

aa423-473 (1)

p182 (1)

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Publications

No (78)

Sample Type

Adherent Cell Cultures (2)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

His-GST (1)

Species

Human (4)

Source

Baculovirus (1)

E. coli (1)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

Select

Mouse/Human Phospho-MAPKAPK5 / PRAK (Thr182) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1735

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$772

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MAPKAPK5 / PRAK Antibody (120-200 aa) LS-C381421

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (120-200 aa) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

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MAPKAPK5 / PRAK Antibody (phospho-Thr182) LS-C415790

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pThr182) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

Select

IHC-plus™ MAPKAPK5 / PRAK Antibody (aa192-206) LS-B9569

(4.0) Rating

Antibody:

MAPKAPK5 / PRAK Goat anti-Human Polyclonal (aa192-206) Antibody

Reactivity:

Chicken, Zebrafish, Pig, Horse, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey

Applications:

IHC, IHC-P, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

Select

MAPKAPK5 / PRAK Antibody (clone 7H10B4) LS-C41490

Antibody:

MAPKAPK5 / PRAK Mouse anti-Human Monoclonal (7H10B4) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$435

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IHC-plus™ MAPKAPK5 / PRAK Antibody (aa306-318) LS-B9567

(4.0) Rating

Antibody:

MAPKAPK5 / PRAK Goat anti-Human Polyclonal (aa306-318) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Pig, Horse, Human, Monkey

Applications:

IHC, IHC-P, IP, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µg/$485

Select

MAPKAPK5 / PRAK Antibody (phospho-Thr182) LS-C800215

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pThr182) Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

Human MAPKAPK5 / PRAK Protein (Recombinant GST) (Full Length) - LS-G31204

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

77.55 kDa

Price:

10 µg/$479; 25 µg/$670

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Mouse/Human MAPKAPK5 / PRAK (Cell-Based ELISA) ELISA Kit - LS-F2129

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

Select

MAPKAPK5 / PRAK Antibody (phospho-Thr182) LS-C199229

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pThr182) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

MAPKAPK5 / PRAK Antibody LS-C812834

Antibody:

MAPKAPK5 / PRAK Mouse anti-Human Monoclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

Select

MAPKAPK5 / PRAK Antibody (phospho-Ser93) LS-C327829

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pSer93) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

MAPKAPK5 / PRAK Antibody (phospho-Ser93, Biotin) LS-C279208

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pSer93) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

MAPKAPK5 / PRAK Antibody (phospho-Ser93, FITC) LS-C279212

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pSer93) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

MAPKAPK5 / PRAK Antibody (phospho-Ser93, PE) LS-C279214

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pSer93) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

MAPKAPK5 / PRAK Antibody (phospho-Ser93, APC) LS-C279209

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pSer93) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

MAPKAPK5 / PRAK Antibody (phospho-Ser93, Azide-free, HRP) LS-C279213

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pSer93) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• PE
• APC
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • PE
  • APC
  • HRP, Azide-free

Select

MAPKAPK5 / PRAK Antibody (phospho-Thr182) LS-C827095

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pThr182) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

MAPKAPK5 / PRAK Antibody (aa423-473) LS-C289343

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (aa423-473) Antibody

Reactivity:

Human

Applications:

IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

MAPKAPK5 / PRAK Antibody (phospho-Ser93) LS-C96899

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pSer93) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

MAPKAPK5 / PRAK Antibody (aa171-220) LS-C199230

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (aa171-220) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

MAPKAPK5 / PRAK Antibody LS-C666651

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

Select

MAPKAPK5 / PRAK Antibody LS-C826749

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

MAPKAPK5 / PRAK Antibody (aa371-471) LS-C308888

Antibody:

MAPKAPK5 / PRAK Mouse anti-Human Monoclonal (aa371-471) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

Select

MAPKAPK5 / PRAK Antibody (phospho-Thr182) LS-C415791

Antibody:

MAPKAPK5 / PRAK Rabbit anti-Human Polyclonal (pThr182) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

50 µg/$305; 100 µg/$357

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