MAPKAPK3

mitogen-activated protein kinase-activated protein kinase 3

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, cell migration, chromatin remodeling and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3, share the same function and substrate specificity, but MAPKAPK3 kinase activity and level in protein expression are lower compared to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins, such as TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3. Also acts as a modulator of Polycomb-mediated repression.

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Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

MAPKAPK3 (8)

Publications

No (8)

Tag

GST (2)

GST, N-terminus (1)

His (1)

His-T7 (1)

Myc-DDK (Flag) (3)

Species

Human (7)

Source

293T Cells (1)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human MAPKAPK3 Protein (Recombinant GST) (Full Length) - LS-G31021

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

67.76 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MAPKAPK3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66301

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$1,107

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Human MAPKAPK3 Protein (Recombinant GST, N-terminus) (aa272-382) - LS-G60619

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAPKAPK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77407

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$150

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MAPKAPK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100355

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

100 µg/$494

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Human MAPKAPK3 Protein (Recombinant GST) (Met1-Gln382) - LS-G97683

Source:

Baculovirus

Tag:

GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

69 kDa

Price:

50 µg/$707

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Human MAPKAPK3 Protein (Recombinant His) - LS-G2024

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human MAPKAPK3 Protein (Recombinant His-T7) (aa129-329) - LS-G14083

Source:

E. coli

Tag:

His-T7

Molecular Weight:

27.0 kDa

Price:

50 µg/$432; 10 µg/$279; 200 µg/$862; 100 µg/$690; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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