Menu
Products
Services
Research Areas
Resources
Contact Us
Distributors
Login
Quick Order
Cart
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order
Services
Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
Contact Us
LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121
Phone:
866-819-4732 (Toll Free North America
206-374-1102 (International)
Fax:
866-206-6909 (Toll Free North America)
206-577-4565 (International)
How To Buy - Details about how to buy our products.
Orders@LSBio.com - To submit a new order.
Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, froforma invoice requests, or other billing issues.
Technical.Support@LSBio.com - To request technical information about an LSBio product or its applications
Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.
Worldwide Distributors List - To find your local distributor if you're not within the United States.
Login
Registration enables users to use special features of this website, such as past
order histories, retained contact details for faster checkout, review submissions, and special promotions.


Fields marked with a * are required.

Login
Quick Order

MAPKAPK2 / MAPKAP Kinase 2

mitogen-activated protein kinase-activated protein kinase 2

Stress-activated serine/threonine-protein kinase involved in cytokines production, endocytosis, reorganization of the cytoskeleton, cell migration, cell cycle control, chromatin remodeling, DNA damage response and transcriptional regulation. Following stress, it is phosphorylated and activated by MAP kinase p38-alpha/MAPK14, leading to phosphorylation of substrates. Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S, where Hyd is a large hydrophobic residue. Phosphorylates ALOX5, CDC25B, CDC25C, ELAVL1, HNRNPA0, HSF1, HSP27/HSPB1, KRT18, KRT20, LIMK1, LSP1, PABPC1, PARN, PDE4A, RCSD1, RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of HSP27/HSPB1 in response to stress, leading to dissociate HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers and impair their chaperone activities and ability to protect against oxidative stress effectively. Involved in inflammatory response by regulating tumor necrosis factor (TNF) and IL6 production post-transcriptionally: acts by phosphorylating AU-rich elements (AREs)-binding proteins ELAVL1, HNRNPA0, PABPC1 and TTP/ZFP36, leading to regulate the stability and translation of TNF and IL6 mRNAs. Phosphorylation of TTP/ZFP36, a major post-transcriptional regulator of TNF, promotes its binding to 14-3-3 proteins and reduces its ARE mRNA affinity leading to inhibition of dependent degradation of ARE-containing transcript. Also involved in late G2/M checkpoint following DNA damage through a process of post-transcriptional mRNA stabilization: following DNA damage, relocalizes from nucleus to cytoplasm and phosphorylates HNRNPA0 and PARN, leading to stabilize GADD45A mRNA. Involved in toll-like receptor signaling pathway (TLR) in dendritic cells: required for acute TLR-induced macropinocytosis by phosphorylating and activating RPS6KA3.

Gene Name: mitogen-activated protein kinase-activated protein kinase 2
Family/Subfamily: Protein Kinase , MAPKAPK
Synonyms: MAPKAPK2, MK-2, MAP KAP Kinase 2, MAPKAP kinase 2, MK2, MAPKAP-K2, MAPKAPK-2
Target Sequences: NM_004759 NP_004750.1 P49137

Viewing 1-25 of 84 items
MAPKAPK2 / MAPKAP Kinase 2 Antibody - Anti-MAPKAPK2 / MK2 antibody IHC staining of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Goat Polyclonal to Human MAPKAPK2 / MAPKAP Kinase 2
Rabbit, Mouse, Dog, Guinea pig, Bovine, Hamster, Pig, Horse, Human
IHC, IHC-P, IP, Peptide-ELISA, WB
Unconjugated
50µg   0.5mg/ml   $425.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody - Anti-MAPKAPK2 / MK2 antibody IHC staining of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:67.
Select
Rabbit Polyclonal to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   $425.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody - MAPKAPK2 monoclonal antibody (M08), clone 3B8. Western blot of MAPKAPK2 expression in PC-12.
Select
Mouse Monoclonal [clone 3B8] (IgG2a,k) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µg   $365.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Human
DB, ELISA, IHC, IP, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Human
DB, ELISA, IHC, IP, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Human
DB, ELISA, IHC, IP, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Human
DB, ELISA, IHC, IP, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Human
DB, ELISA, IHC, IP, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Human
DB, ELISA, IHC, IP, WB
HRP Conjugated, Azide-free
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Chicken, Zebrafish, Rat, Rabbit, Mouse, Dog, Bovine, Human, Monkey
IHC, WB
Unconjugated
50µg   $435.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody - Immunofluorescence staining of methanol-fixed HeLa cells using MAPKAPK-2(Ab-334) antibody.
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
IF, WB
Unconjugated
50µl   1mg/ml   $295.00; 100µl   1mg/ml   $355.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody - Immunofluorescence of monoclonal antibody to MAPKAPK2 on HeLa cell. [antibody concentration 10 ug/ml]
Select
Mouse Monoclonal [clone 2B3] (IgG2b,k) to Human MAPKAPK2 / MAPKAP Kinase 2
Human
ELISA, IF, IP, WB
Unconjugated
100µg   $365.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MAPKAPK2 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody - Immunohistochemistry analysis of paraffin-embedded human heart tissue, using MAPKAPK2 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MAPKAPK2 Antibody. The picture on the right is blocked with the synthesized peptide.
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody - Immunohistochemistry analysis of paraffin-embedded human heart, using MAPKAPK-2 (Phospho-Thr222) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using MAPKAPK2 (Phospho-Ser272) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody - Immunohistochemistry analysis of paraffin-embedded human brain, using MAPKAPK2 (Phospho-Thr334) Antibody. The picture on the right is blocked with the phospho peptide.
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50µl   1mg/ml   $265.00; 100µl   1mg/ml   $325.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human, Monkey
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Human
ELISA, IHC, WB
Unconjugated
100µg   $355.00
MAPKAPK2 / MAPKAP Kinase 2 Antibody
Select
Rabbit Polyclonal (IgG) to Human MAPKAPK2 / MAPKAP Kinase 2
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00

Viewing 1-25 of 84 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).