MAPKAP1 / MIP1

mitogen-activated protein kinase associated protein 1

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

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Proteins (12)

Type

Over-Expression Lysate (8)

Recombinant (4)

Target

MAPKAP1 / MIP1 (12)

Publications

No (12)

Tag

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (8)

Myc-DDK (Flag), C-terminus (1)

Species

Human (8)

Source

293T Cells (4)

E. coli (1)

HEK 293 Cells (5)

Wheat Germ Extract (2)

Purification

Purified (2)

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MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122019

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.1 kDa

Price:

100 µg/$494

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MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G122190

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.9 kDa

Price:

100 µg/$710

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MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110039

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.8 kDa

Price:

100 µg/$494

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Human MAPKAP1 / MIP1 Protein (Recombinant Myc-DDK (Flag), C-terminus) (Full Length) - LS-G142148

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag), C-terminus

Molecular Weight:

58.9 kDa

Price:

20 µg/$1,107

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Human MAPKAP1 / MIP1 Protein (Recombinant GST) (Full Length) - LS-G35154

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

62.6 kDa

Price:

2 µg/$439

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Human MAPKAP1 / MIP1 Protein (Recombinant 6His-SUMO, N-terminus) (aa2-522) - LS-G57560

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human MAPKAP1 / MIP1 Protein (Recombinant GST, N-terminus) (aa51-160) - LS-G63160

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81292

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.1 kDa

Price:

20 µg/$150

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Human MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81293

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.9 kDa

Price:

20 µg/$215

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Human MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81294

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.1 kDa

Price:

20 µg/$150

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Human MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81297

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

54.8 kDa

Price:

20 µg/$150

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MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99266

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.1 kDa

Price:

100 µg/$494

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