LSBio
LSBio
Products
Services
Research Areas
Resources
Contact Us
Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

LSBio
2401 Fourth Avenue Suite 900
Seattle WA 98121

Phone: 866-819-4732 (Toll Free North America)
206-374-1102 (International)

Fax: 866-206-6909 (Toll Free North America)
206-577-4565 (International)

How to Buy - Details about how to buy our products.

Orders@LSBio.com - To submit a new order.

Customer.Support@LSBio.com - To submit questions about existing orders, pricing, availability, bulk quotes, proforma invoice requests, or other billing issues.

Technical.Support@LSBio.com - To request technical information requests about an LSBio product or its application.

Sales@LSBio.com - To request information about fee-for-service contract IHC studies, IHC reports, distribution agreements, or general business development.

Worldwide Distributors List - To find your local distributor if you're not within the United States.
Products
Services
Research Areas
Resources
Contact Us

MAPKAP1 / MIP1

mitogen-activated protein kinase associated protein 1

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

Gene Name: mitogen-activated protein kinase associated protein 1
Family/Subfamily: Protein Kinase
Synonyms: MAPKAP1, MSIN1, SAPK-interacting protein 1, SIN1b, TORC2 subunit MAPKAP1, Ras inhibitor MGC2745, SIN1, SIN1g, JC310, MEKK2-interacting protein 1, Mip1
Target Sequences: NM_001006617 NP_001006618.1 Q9BPZ7

Filtered By: None
Target
MAPKAP1 / MIP1 (31)
Reactivity
Human (31)
Mouse (17)
Rat (17)
Bat (1)
Bovine (4)
Chicken (3)
Dog (5)
Horse (3)
Monkey (1)
Rabbit (1)
Sheep (3)
Zebrafish (1)
Application
IHC (17)
IHC-P (7)
WB (29)
ELISA (10)
IF (4)
IP (1)
PLA (1)
Host
rabbit (31)
Isotype
IgG (26)
Clonality
polyclonal pc (31)
Format
AP Conjugated (3)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (2)
Unconjugated (19)
Epitope
aa481-510 (8)
C-Terminus (3)
Internal (2)
N-Terminus (1)
aa1-290 (1)
aa100-150 (1)
aa250-522 (1)
aa85-102 (1)
Publications
No (31)
Showing 1-25 of 31 results

MAPKAP1 / MIP1 Antibody (N-Terminus) IHC-plus™ LS-B585
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IF IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-SIN1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of MAPKAP1 in Human Skeletal Muscle cells with MAPKAP1 antibody at 20 ug/ml.
Anti-SIN1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Immunofluorescence of MAPKAP1 in Human Skeletal Muscle cells with MAPKAP1 antibody at 20 ug/ml.

MAPKAP1 / MIP1 Antibody LS-C666648
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Human
ELISA IF IHC WB
Unconjugated
100µg  $335.00

MAPKAP1 / MIP1 Antibody (aa100-150) IHC-plus™ LS-B6519
Rabbit Polyclonal to Human MAPKAP1 / MIP1
Mouse, Dog, Bovine, Rat, Human
IHC IHC-P WB
Unconjugated
50µg  $425.00
Anti-SIN1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of MAPKAP1 interacting protein 1 in human skeletal muscle lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse skeletal muscle lysate and 4) rat skeletal muscle lysate using antibody at2 ug/ml.
Anti-SIN1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Western blot of MAPKAP1 interacting protein 1 in human skeletal muscle lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse skeletal muscle lysate and 4) rat skeletal muscle lysate using antibody at2 ug/ml.

MAPKAP1 / MIP1 Antibody (Internal) IHC-plus™ LS-B1376
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
50µg 1mg/ml  $425.00
Anti-SIN1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Western blot of MAPKAP1 in human skeletal muscle tissue lysate with MAPKAP1 antibody at (A) 1 and (B) 2 ug/ml.
Anti-SIN1 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Western blot of MAPKAP1 in human skeletal muscle tissue lysate with MAPKAP1 antibody at (A) 1 and (B) 2 ug/ml.

MAPKAP1 / MIP1 Antibody (C-Terminus) LS-C287748
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Chicken, Sheep, Bovine, Mouse, Dog, Rat, Horse, Human
IF IHC IHC-P IP PLA WB
Unconjugated
100µl 1mg/ml  $395.00
Detection of Human Sin1 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-Sin1 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
Detection of Human Sin1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (50 and 15 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Sin1 antibody used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate (B). Detection: Chemiluminescence with exposure times of 7 minutes (A) and 30 seconds (B).
Detection of Human Sin1 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-Sin1 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.
Detection of Human Sin1 by Western Blot and Immunoprecipitation. Samples: Whole cell lysate (50 and 15 ug for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-Sin1 antibody used for WB at 0.1 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate (B). Detection: Chemiluminescence with exposure times of 7 minutes (A) and 30 seconds (B).

MAPKAP1 / MIP1 Antibody (C-Terminus) LS-C285957
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Chicken, Sheep, Bovine, Mouse, Dog, Rat, Horse, Human
IF IHC IHC-P
Unconjugated
100µl  $415.00
Detection of Human Sin1 by Immunohistochemistry. Sample: FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-Sin1 used at a dilution of 1:500.
Detection of Mouse Sin1 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-Sin1 used at a dilution of 1:100.
Detection of Human Sin1 by Immunohistochemistry. Sample: FFPE section of human prostate adenocarcinoma. Antibody: Affinity purified rabbit anti-Sin1 used at a dilution of 1:500.
Detection of Mouse Sin1 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma. Antibody: Affinity purified rabbit anti-Sin1 used at a dilution of 1:100.

MAPKAP1 / MIP1 Antibody LS-C666649
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Human
ELISA IHC WB
Unconjugated
100µg  $355.00

MAPKAP1 / MIP1 Antibody (Internal) LS-C121251
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µg  $530.00

MAPKAP1 / MIP1 Antibody (HRP) LS-C547787
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IHC WB
HRP Conjugated
100µl  $710.00

MAPKAP1 / MIP1 Antibody (Biotin) LS-C527689
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IHC WB
Biotin Conjugated
100µl  $710.00

MAPKAP1 / MIP1 Antibody (FITC) LS-C537652
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IHC WB
FITC Conjugated
100µl  $710.00

MAPKAP1 / MIP1 Antibody (AP) LS-C509657
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IHC WB
AP Conjugated
100µl  $710.00

MAPKAP1 / MIP1 Antibody (PE) LS-C655820
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IHC WB
PE Conjugated
100µl  $710.00

MAPKAP1 / MIP1 Antibody LS-C187780
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IHC IHC-P WB
Unconjugated
100µg 1mg/ml  $355.00

MAPKAP1 / MIP1 Antibody LS-C412419
Rabbit Polyclonal to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IHC WB
Unconjugated
100µl  $385.00

MAPKAP1 / MIP1 Antibody (aa481-510) LS-C329814
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Human
ELISA WB
Unconjugated
200µl  $530.00

MAPKAP1 / MIP1 Antibody (aa481-510, Biotin) LS-C207214
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Human
ELISA WB
Biotin Conjugated
200µl  $680.00

MAPKAP1 / MIP1 Antibody (aa481-510, FITC) LS-C207217
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Human
ELISA WB
FITC Conjugated
200µl  $680.00

MAPKAP1 / MIP1 Antibody (aa481-510, APC) LS-C207215
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Human
ELISA WB
APC Conjugated
200µl  $680.00

MAPKAP1 / MIP1 Antibody (aa481-510, AP) LS-C207216
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Human
ELISA WB
AP Conjugated
200µl  $680.00

MAPKAP1 / MIP1 Antibody (aa481-510, Azide-free, HRP) LS-C207218
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Human
ELISA WB
HRP Conjugated, Azide-free
200µl  $680.00

MAPKAP1 / MIP1 Antibody (aa481-510, PE) LS-C207221
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Human
ELISA WB
PE Conjugated
200µl  $680.00

MAPKAP1 / MIP1 Antibody (aa1-290) LS-C379207
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Human
ELISA WB
Unconjugated
50µl  $285.00; 100µl  $385.00
Western blot. All lanes: Target of rapamycin complex 2 subunit MAPKAP1 antibody at 2 ug/ml. Lane 1: HeLa whole cell lysate. Lane 2: MCF-7 whole cell lysate. secondary Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 59 kDa. Observed band size: 59 kDa.
Western blot. All lanes: Target of rapamycin complex 2 subunit MAPKAP1 antibody at 2 ug/ml. Lane 1: HeLa whole cell lysate. Lane 2: MCF-7 whole cell lysate. secondary Goat polyclonal to rabbit at 1:10000 dilution. Predicted band size: 59 kDa. Observed band size: 59 kDa.

MAPKAP1 / MIP1 Antibody (AP) LS-C409007
Rabbit Polyclonal (IgG) to Human MAPKAP1 / MIP1
Mouse, Rat, Human
IHC WB
AP Conjugated
50µl  $255.00; 100µl  $315.00; 200µl  $425.00

MAPKAP1 / MIP1 Antibody LS-C147076
Rabbit Polyclonal to Mouse MAPKAP1 / MIP1
Mouse, Rat, Human
WB
Unconjugated
30µg  $245.00; 100µg  $405.00
Showing 1-25 of 31 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

Get Social With Us!
Follow us on Facebook Follow us on Google+ Follow us on LinkedIn PSL Alliance Member
Copyright © 2018 LifeSpan BioSciences, Inc. All Rights Reserved Privacy Policy