MAPKAP1 / MIP1

mitogen-activated protein kinase associated protein 1

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex.

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Products

Antibodies (19)

Proteins (12)

ELISA Kits (1)

Type

Over-Expression Lysate (8)

Primary (19)

Recombinant (4)

Sandwich (1)

Target

MAPKAP1 / MIP1 (32)

Reactivity

Human (20)

Mouse (7)

Rat (6)

Bat (1)

Bovine (2)

Chicken (1)

Dog (3)

Horse (1)

Monkey (1)

Rabbit (1)

Sheep (1)

Zebrafish (1)

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Application

IHC (9)

IHC-P (5)

WB (17)

ELISA (11)

IF (2)

IP (1)

Host

rabbit (19)

Product Group

IHCPlus (3)

Isotype

IgG (17)

Clonality

polyclonal pc (19)

Format

96-Well Strip Plate (1)

AP Conjugated (1)

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (1)

FITC Conjugated (1)

HRP Conjugated (1)

PE Conjugated (1)

Unconjugated (13)

Epitope

aa481-510 (7)

aa470-C-term (2)

C-Terminus (1)

aa1-290 (1)

aa100-150 (1)

aa85-102 (1)

Publications

No (32)

Sample Type

Cell Culture Supernatants (1)

Cell Lysates (1)

Plasma (1)

Serum (1)

Tissue Homogenates (1)

Tag

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (8)

Myc-DDK (Flag), C-terminus (1)

Species

Human (8)

Source

293T Cells (4)

E. coli (1)

HEK 293 Cells (5)

Wheat Germ Extract (2)

Purification

Purified (2)

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IHC-plus™ MAPKAP1 / MIP1 Antibody LS-B585

(4.0) Rating

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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MAPKAP1 / MIP1 Antibody LS-C666648

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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IHC-plus™ MAPKAP1 / MIP1 Antibody (aa100-150) LS-B6519

(4.0) Rating

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa100-150) Antibody

Reactivity:

Mouse, Dog, Bovine, Rat, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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IHC-plus™ MAPKAP1 / MIP1 Antibody LS-B1376

(4.0) Rating

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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MAPKAP1 / MIP1 Antibody (aa470-C-term) LS-C287748

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa470-C-term) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

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MAPKAP1 / MIP1 Antibody LS-C666649

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$341

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MAPKAP1 / MIP1 Antibody (aa481-510) LS-C329814

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa481-510) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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MAPKAP1 / MIP1 Antibody (aa481-510, Biotin) LS-C207214

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa481-510) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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MAPKAP1 / MIP1 Antibody (aa481-510, FITC) LS-C207217

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa481-510) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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MAPKAP1 / MIP1 Antibody (aa481-510, APC) LS-C207215

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa481-510) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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MAPKAP1 / MIP1 Antibody (aa481-510, Azide-free, HRP) LS-C207218

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa481-510) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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MAPKAP1 / MIP1 Antibody (aa481-510, PE) LS-C207221

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa481-510) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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MAPKAP1 / MIP1 Antibody (aa470-C-term) LS-C285957

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa470-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

1 µg/$295; 100 µl/$532

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MAPKAP1 / MIP1 Antibody (aa1-290) LS-C379207

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa1-290) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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MAPKAP1 / MIP1 Antibody (AP) LS-C409007

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (AP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, WB

Format:

AP Conjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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MAPKAP1 / MIP1 Antibody LS-C137292

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IHC

Format:

Unconjugated

Price:

100 µl/$332

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MAPKAP1 / MIP1 Antibody (aa85-102) LS-C47276

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa85-102) Antibody

Reactivity:

Chicken, Zebrafish, Horse, Bat, Rabbit, Mouse, Dog, Sheep, Bovine, Rat, Human, Monkey

Applications:

WB

Format:

Unconjugated

Price:

100 µg/$386

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MAPKAP1 / MIP1 Antibody (aa481-510) LS-C164025

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (aa481-510) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

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MAPKAP1 / MIP1 Antibody (C-Terminus) LS-C358044

Antibody:

MAPKAP1 / MIP1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Mouse, Dog, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

25 µg/$364; 100 µg/$511

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Human MAPKAP1 / MIP1 Protein (Recombinant 6His-SUMO, N-terminus) (aa2-522) - LS-G57560

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human MAPKAP1 / MIP1 Protein (Recombinant GST, N-terminus) (aa51-160) - LS-G63160

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human MAPKAP1 / MIP1 (Sandwich ELISA) ELISA Kit - LS-F55011

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Culture Supernatants, Cell Lysates, Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$834

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Human MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81293

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

58.9 kDa

Price:

20 µg/$215

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Human MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81294

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.1 kDa

Price:

20 µg/$150

Select

Human MAPKAP1 / MIP1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81292

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

36.1 kDa

Price:

20 µg/$150

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