MAPK9 / JNK2

mitogen-activated protein kinase 9

Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2. In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells. Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels. Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption. When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway. Participates also in neurite growth in spiral ganglion neurons.MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.

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Products

Proteins (18)

Type

Over-Expression Lysate (8)

Recombinant (10)

Target

MAPK9 / JNK2 (18)

Publications

No (18)

Tag

6His-SUMO, N-terminus (1)

GST (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (11)

Species

Human (14)

Source

293T Cells (4)

Baculovirus (1)

E. coli (4)

HEK 293 Cells (7)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human MAPK9 / JNK2 Protein (Recombinant 6His-SUMO, N-terminus) (Full Length) - LS-G20951

Source:

E. coli

Tag:

6His-SUMO, N-terminus

Molecular Weight:

64.11 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

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Human MAPK9 / JNK2 Protein (Recombinant GST, N-terminus) (aa321-424) - LS-G59748

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAPK9 / JNK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70830

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

20 µg/$1,107

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Human MAPK9 / JNK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70832

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

20 µg/$1,107

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Human MAPK9 / JNK2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70833

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

20 µg/$1,107

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Human MAPK9 / JNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88121

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

20 µg/$150

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Human MAPK9 / JNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88123

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

20 µg/$150

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Human MAPK9 / JNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88125

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44 kDa

Price:

20 µg/$150

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Human MAPK9 / JNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G88126

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

20 µg/$215

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Human MAPK9 / JNK2 Protein (Recombinant His) (Met1-Arg424) - LS-G97681

Source:

Baculovirus

Tag:

His

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

49.5 kDa

Price:

50 µg/$661; 500 µg/$3,499

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Human MAPK9 / JNK2 Protein (Recombinant His-T7) (aa130-387) - LS-G15345

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.3 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human MAPK9 / JNK2 Protein (Recombinant GST) (Full Length) - LS-G29919

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

72.27 kDa

Price:

10 µg/$479; 25 µg/$670

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MAPK9 / JNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107122

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44 kDa

Price:

100 µg/$494

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MAPK9 / JNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107123

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43.9 kDa

Price:

100 µg/$494

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MAPK9 / JNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G107124

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.1 kDa

Price:

100 µg/$710

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MAPK9 / JNK2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99858

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48 kDa

Price:

100 µg/$494

Select

Human MAPK9 / JNK2 Protein (Recombinant His, N-Terminal) - LS-G145013

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

44 kDa

Price:

50 µg/$419

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Human MAPK9 / JNK2 Protein (Recombinant His) - LS-G1869

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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