MAPK7 / ERK5

mitogen-activated protein kinase 7

ERK5, a MAPK type protein kinase, mediates growth factor stimulated cell proliferation and muscle cell differentiation. ERK5 differs from other MAP kinases in that it contains a unique loop-12 region within the protein kinase domain which is followed by an extensive C-terminal tail with sequences indicating that it may be targeted to the cytoskeleton. ERK5 is phosphorylated and activated by MEK5 in response to osmotic shock, growth factors and oxidant stress. Activated ERK5 phosphorylates myocyte enhancer factor 2 (MEF2), Sap1, NF-kappaB and p90 ribosomal S6 kinase (RSK/MAPKAPK1). ERK (-/-) mice are defective in blood-vessel and cardiac development. At least four alternatively spliced transcript variants of this gene encoding two distinct protein isoforms, 677 and 815 amino acids, have been identified. ERK5 has been shown to participate in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2.

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Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

MAPK7 / ERK5 (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

His-GST (1)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (6)

Mouse (1)

Source

293T Cells (2)

E. coli (2)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human MAPK7 / ERK5 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65599

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

88.2 kDa

Price:

20 µg/$1,107

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Human MAPK7 / ERK5 Protein (Recombinant GST, N-terminus) (aa561-677) - LS-G59745

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAPK7 / ERK5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75872

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

88.2 kDa

Price:

20 µg/$150

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Human MAPK7 / ERK5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75873

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73 kDa

Price:

20 µg/$150

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Human MAPK7 / ERK5 Protein (Recombinant His-GST) (aa560-793) - LS-G13789

Source:

E. coli

Tag:

His-GST

Molecular Weight:

55.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Mouse MAPK7 / ERK5 Protein (Recombinant His-T7) (aa185-419) - LS-G13793

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.5 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human MAPK7 / ERK5 Protein (Recombinant GST) (Full Length) - LS-G29915

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

100.21 kDa

Price:

2 µg/$439

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MAPK7 / ERK5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102258

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

73 kDa

Price:

100 µg/$494

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MAPK7 / ERK5 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117785

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

88.2 kDa

Price:

100 µg/$494

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