MAPK7 / ERK5

mitogen-activated protein kinase 7

ERK5, a MAPK type protein kinase, mediates growth factor stimulated cell proliferation and muscle cell differentiation. ERK5 differs from other MAP kinases in that it contains a unique loop-12 region within the protein kinase domain which is followed by an extensive C-terminal tail with sequences indicating that it may be targeted to the cytoskeleton. ERK5 is phosphorylated and activated by MEK5 in response to osmotic shock, growth factors and oxidant stress. Activated ERK5 phosphorylates myocyte enhancer factor 2 (MEF2), Sap1, NF-kappaB and p90 ribosomal S6 kinase (RSK/MAPKAPK1). ERK (-/-) mice are defective in blood-vessel and cardiac development. At least four alternatively spliced transcript variants of this gene encoding two distinct protein isoforms, 677 and 815 amino acids, have been identified. ERK5 has been shown to participate in neuregulin signal transduction and is constitutively active in breast cancer cells overexpressing ErbB2.

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