MAPK3 / ERK1

mitogen-activated protein kinase 3

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.

☰ Filters

Products

Proteins (14)

Type

Over-Expression Lysate (7)

Recombinant (7)

Target

MAPK3 / ERK1 (14)

Publications

No (14)

Tag

GST (1)

GST, N-terminus (1)

His (2)

His, N-Terminal (1)

His-T7 (1)

Myc-DDK (Flag) (8)

Species

Human (11)

Source

293T Cells (4)

E. coli (4)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (3)

Select

Human MAPK3 / ERK1 Protein (Recombinant His) (aa11-379) - LS-G20949

Source:

E. coli

Tag:

His

Molecular Weight:

46.4 kD

Price:

1 mg/$1,355; 100 µg/$420; 20 µg/$323

Select

Human MAPK3 / ERK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65595

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43 kDa

Price:

20 µg/$1,107

Select

Human MAPK3 / ERK1 Protein (Recombinant GST, N-terminus) (aa279-379) - LS-G59742

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human MAPK3 / ERK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75864

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.9 kDa

Price:

20 µg/$150

Select

Human MAPK3 / ERK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75865

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.9 kDa

Price:

20 µg/$150

Select

Human MAPK3 / ERK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75866

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.1 kDa

Price:

20 µg/$150

Select

Human MAPK3 / ERK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75867

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43 kDa

Price:

20 µg/$150

Select

Human MAPK3 / ERK1 Protein (Recombinant His, N-Terminal) (Ala2-Pro379) - LS-G96809

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

46 kDa

Price:

10 µg/$265; 100 µg/$365; 250 µg/$518; 50 µg/$315; 500 µg/$949

Select

Human MAPK3 / ERK1 Protein (Recombinant His-T7) (aa75-312) - LS-G24289

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.5 kDa

Price:

10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176

Select

Human MAPK3 / ERK1 Protein (Recombinant GST) (Full Length) - LS-G29913

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.5 kDa

Price:

10 µg/$479; 25 µg/$670

Select

MAPK3 / ERK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99852

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

43 kDa

Price:

100 µg/$494

Select

MAPK3 / ERK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124182

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

38.1 kDa

Price:

100 µg/$494

Select

Human MAPK3 / ERK1 Protein (Recombinant His) - LS-G923

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

Select

MAPK3 / ERK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G120444

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.9 kDa

Price:

100 µg/$494

Viewing 1-14 of 14 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.