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MAPK14 / p38

mitogen-activated protein kinase 14

MAP kinase p38 alpha, a MAPK type protein kinase, is an environmental stress- and inflammatory cytokine-induced kinase that is associated with the regulation of gene expression, cell proliferation and cell death. p38alpha is phosphorylated by MEK3/MAP2K3 or MKK6/MAP2K6. Activated p38alpha either remains in the cytosol, where it phosphorylates cytosolic proteins including MNK1/2, PLA2 and PRAK, or translocates to the nucleus, where it phosphorylates several substrates, including ATF2, CHOP/GADD153, MAPKAPK-2 and -3, MEF2-A and -C, MSK, Myc binding partner Max and Sap-1a. At least four protein isoforms, resulting from alternatively spliced transcript variants of this gene, have been identified - 297, 307 and two isoforms of 360 amino acids with differing internal segments.

Gene Name: mitogen-activated protein kinase 14
Family/Subfamily: Protein Kinase , MAPK
Synonyms: MAPK14, CSAID-binding protein, CSBP2, CSPB1, CSBP1, Csaids binding protein, CSBP, EXIP, MAP kinase 14, MAP kinase p38 alpha, MAX-interacting protein 2, MAPK 14, p38 alpha, PRKM15, PRKM14, RK, SAPK2A, MAP kinase MXI2, Mxi2, p38ALPHA, p38, p38 MAP kinase, p38alpha Exip
Target Sequences: NM_001315 NP_001306.1 Q16539

Publications (3)

1
Preconditioning by inhaled nitric oxide prevents hyperoxic and ischemia/reperfusion injury in rat lungs. Waldow T, Witt W, Ulmer A, Janke A, Alexiou K, Matschke K. Pulmonary pharmacology & therapeutics. 2008 21:418-29. (WB) [PubMed:18453045]
2
Differential and correlated expressions of p16/p21/p27/p38 in mammary gland tumors of aged dogs. Kim HW, Ju JH, Shin JI, Seung BJ, Sur JH. Journal of veterinary science. 2017 December;18:479-485. (Rat) [Full Text Article] [PubMed:28927257] [PMC:PMC5746441] Related Antibodies: LS-C212.
3
Critical role for integrin-4 in the attenuation of murine acute lung injury by simvastatin. Chen W, Sammani S, Mitra S, Ma SF, Garcia JG, Jacobson JR. American journal of physiology. Lung cellular and molecular physiology. 2012 303:L279-85. [PubMed:22683568] [PMC:PMC3423831] Related Antibodies: LS-B1634.

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Antibodies (185)
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MAPK14 / p38 (225)
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MAPK14 / p38 Antibody - Anti-MAPK14 / p38 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:100.
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MAPK14 / p38 Rabbit anti-Mouse Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MAPK14 / p38 Antibody - Western blot of C-6 glioma cell lysates in the presence of Anisomycin showing specific immunolabeling of the ~39k p38 protein phosphorylated at Thr180 and Tyr182 (Anisomycin). The immunolabeling is absent without Anisomycin (Control).
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MAPK14 / p38 Rabbit anti-Rat Polyclonal (pThr180/Tyr182) Antibody
Chicken, Bovine, Mouse, Dog, Rat, Human
IHC, WB
Unconjugated
100 µl/$469
MAPK14 / p38 Antibody - Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using p38 MAPK (Phospho-Tyr182) Antibody. The picture on the right is blocked with the phospho peptide.
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MAPK14 / p38 Rabbit anti-Human Polyclonal (pTyr182) Antibody
Mouse, Rat, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
MAPK14 / p38 Antibody - IHC of paraffin-embedded cervical cancer tissues using MAPK14 mouse monoclonal antibody with DAB staining.
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MAPK14 / p38 Mouse anti-Human Monoclonal (aa299-360) (8G4D11) Antibody
Human
ELISA, Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$459
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MAPK14 / p38 Mouse anti-Human Monoclonal (N-Terminus) Antibody
Mouse, Human
ELISA, IP, WB
Unconjugated
100 µg/$794
MAPK14 / p38 Antibody - Multi-blot analysis of p38 in a cell lysate from 12 human cancer cell lines using a 1:1000 dilution of MAPK14 / p38 antibody.
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MAPK14 / p38 Rabbit anti-Human Polyclonal Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Rat, Hamster, Pig, Human, Monkey
IHC, IP, WB
Unconjugated
25 µl/$290; 100 µl/$372
MAPK14 / p38 Antibody - Anti-MAPK14 / p38 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAPK14 / p38 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
MAPK14 / p38 Antibody - Anti-MAPK14 / p38 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAPK14 / p38 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Chicken, Sheep, Bovine, Rabbit, Mouse, Dog, Guinea pig, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
MAPK14 / p38 Antibody - MAPK14 Antibody (Y322) western blot of Jurkat cell line and mouse kidney tissue lysates (35 ug/lane). The MAPK14 antibody detected the MAPK14 protein (arrow).
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MAPK14 / p38 Rabbit anti-Human Polyclonal (Tyr323) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
MAPK14 / p38 Antibody - Immunohistochemical analysis of p38 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MAPK14 / p38 Rabbit anti-Human Polyclonal (Internal) Antibody
Zebrafish, Rat, Mouse, Dog, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$299
MAPK14 / p38 Antibody - Western blot of Phospho-p38 (Y323) antibody
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MAPK14 / p38 Rabbit anti-Human Polyclonal (260-340 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MAPK14 / p38 Antibody - 1:200 staining human kidney tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MAPK14 / p38 Rabbit anti-Human Polyclonal (pTyr182) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MAPK14 / p38 Protein
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E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
MAPK14 / p38 Antibody - Immunofluorescence analysis of NIH-3T3 cells using MAPK14 antibody.
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MAPK14 / p38 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
20 µl/$275; 50 µl/$325; 100 µl/$409; 200 µl/$527
MAPK14 / p38 Antibody - MAPK14 Antibody (T180/Y182)immunohistochemistry of formalin-fixed and paraffin-embedded human lung carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of the MAPK14 Antibody (T180/Y182) for immunohistochemistry.
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MAPK14 / p38 Rabbit anti-Human Polyclonal (Thr180/Tyr182) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
MAPK14 / p38 Antibody - Immunohistochemical analysis of p38 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MAPK14 / p38 Rabbit anti-Human Polyclonal (Internal) Antibody
Zebrafish, Rat, Mouse, Dog, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$321
MAPK14 / p38 Antibody - Western blot of Activator of 90 kDa heat shock protein ATPase homolog 1 antibody at 2 ug/ml. Lane 1: EC109 whole cell lysate. Lane 2: 293T whole cell lysate. Secondary: Goat polyclonal to Rabbit IgG at 1:15000 dilution. Predicted band size: 37 kDa. Observed band size: 45 kDa.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAPK14 / p38 Rabbit anti-Human Polyclonal (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
50 µg/$294; 100 µg/$360
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MAPK14 / p38 Rabbit anti-Human Polyclonal (pTyr182) Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µg/$489
MAPK14 / p38 Antibody - Western blot of p38 antibody
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MAPK14 / p38 Rabbit anti-Human Polyclonal (260-340 aa) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MAPK14 / p38 Antibody - Immunohistochemical analysis of p38 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected with HRP and DAB as chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
MAPK14 / p38 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Zebrafish, Rat, Mouse, Dog, Human
ICC, IF, IHC, IHC-P, IP, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
MAPK14 / p38 Antibody - Immunohistochemical analysis of p38 (pY182) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
Select
MAPK14 / p38 Rabbit anti-Human Polyclonal (pTyr182) Antibody
Zebrafish, Rat, Mouse, Dog, Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$341
MAPK14 / p38 Antibody - 1:100 staining mouse pancreas tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MAPK14 / p38 Rabbit anti-Human Polyclonal (pTyr323) Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
MAPK14 / p38 Antibody - Peptide - + Immunohistochemistry analysis of paraffin-embedded human brain tissue using p38 MAPK (Ab-322) antibody.
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MAPK14 / p38 Rabbit anti-Human Polyclonal (p322) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$357
MAPK14 / p38 Antibody - Western blot of p38 MAPK expression in 293 whole cell lysates,The lane on the left is treated with the antigen-specific peptide.
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MAPK14 / p38 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
Select
MAPK14 / p38 Rabbit anti-Human Polyclonal (aa157-192) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
Viewing 1-25 of 225 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).