MAPK10 / JNK3

mitogen-activated protein kinase 10

Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.

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Proteins (9)

Type

Over-Expression Lysate (4)

Recombinant (5)

Target

MAPK10 / JNK3 (9)

Publications

No (9)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Myc-DDK (Flag) (6)

Species

Human (7)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (4)

Wheat Germ Extract (2)

Purification

Purified (1)

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MAPK10 / JNK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G117784

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.4 kDa

Price:

100 µg/$494

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Human MAPK10 / JNK3 Protein (Recombinant GST) (Full Length) - LS-G29920

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

60.83 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MAPK10 / JNK3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67033

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.4 kDa

Price:

20 µg/$1,107

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Human MAPK10 / JNK3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67034

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.4 kDa

Price:

20 µg/$1,107

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Human MAPK10 / JNK3 Protein (Recombinant GST, N-terminus) (aa219-319) - LS-G59749

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human MAPK10 / JNK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78972

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

48.4 kDa

Price:

20 µg/$150

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Human MAPK10 / JNK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G78974

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.4 kDa

Price:

20 µg/$215

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MAPK10 / JNK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102257

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

52.4 kDa

Price:

100 µg/$710

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Human MAPK10 / JNK3 Protein (Recombinant His-T7) (aa88-332) - LS-G14381

Source:

E. coli

Tag:

His-T7

Molecular Weight:

31.9 kDa

Price:

10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204

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