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MAPK10 / JNK3
mitogen-activated protein kinase 10
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.
| Gene Name: | mitogen-activated protein kinase 10 |
| Family/Subfamily: | Protein Kinase , MAPK |
| Synonyms: | MAPK10, C-Jun N-terminal kinase 3, JNK3, JNK3A, MAPK 10, MAP kinase 10, MAP kinase p49 3F12, p493F12, p54B SAPK, SAPK beta, p54bSAPK, SAPK1b, Serk 2, JNK3 alpha protein kinase, PRKM10 |
| Target Sequences: | NM_002753 NP_002744.1 P53779 |
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