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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MAPK1 / ERK2

mitogen-activated protein kinase 1

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

Gene Name: mitogen-activated protein kinase 1
Family/Subfamily: Protein Kinase , MAPK
Synonyms: MAPK1, ERK, ERK-2, ERK2, MAP kinase 1, MAPK 2, MAPK2, MAP kinase isoform p42, MAPK 1, p41mapk, PRKM2, MAP kinase 2, p41, p42-MAPK, PRKM1, ERT1, p38, p40, p42MAPK, Protein tyrosine kinase ERK2
Target Sequences: NM_002745 NP_002736.3 P28482

Viewing 1-25 of 195 items
MAPK1 / ERK2 Antibody - Anti-MAPK1 / ERK antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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Rabbit Polyclonal (IgG) to Rat MAPK1 / ERK2
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50µl   $425.00
MAPK1 / ERK2 Antibody - Anti-MAPK1 / ERK antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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Mouse Monoclonal [clone 4C11C11C4] (IgG2a) to Human MAPK1 / ERK2
Human
ELISA, IHC, IHC-Fr, IHC-P, WB
Unconjugated
50µg   $425.00
MAPK1 / ERK2 Antibody - Anti-MAPK1 / ERK antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:50.
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Mouse Monoclonal (IgG1,k) to Human MAPK1 / ERK2
Mouse, Rat, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
MAPK1 / ERK2 Antibody - Anti-MAPK1 / ERK2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
MAPK1 / ERK2 Antibody - Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE)
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Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50µl   1mg/ml   $425.00
Select
Rabbit Monoclonal (IgG) to Human MAPK1 / ERK2
Mouse, Rat, Human, Monkey
ELISA, Flo, ICC, IF, IP, WB
Unconjugated
200µl   $590.00
MAPK1 / ERK2 Antibody - Western blot of ERK 2 antibody
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Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
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Mouse Monoclonal (IgG1) to Human MAPK1 / ERK2
Mouse, Rat, Human
Flo, IP, WB
Unconjugated
100µl   $575.00
Select
Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Drosophila, Rat, Mouse, Human, Monkey
IHC, IHC-P, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Mouse MAPK1 / ERK2
Mouse, Rat, Human
IP, WB
Unconjugated
200µg   $815.00
MAPK1 / ERK2 Antibody - IHC of paraffin-embedded pancreas tissue using anti-MAPK1 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI4C2] (IgG1) to Human MAPK1 / ERK2
Dog, Rat, Human, Monkey
IF, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $345.00
MAPK1 / ERK2 Antibody - IHC of paraffin-embedded pancreas tissue using anti-MAPK1 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI4C2] (IgG1) to Human MAPK1 / ERK2
Dog, Rat, Human, Monkey
IF, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
MAPK1 / ERK2 Antibody - IHC using p42 MAP Kinase / ERK2 / MAPK1 Antibody (4C11)
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Mouse Monoclonal [clone 4C11] (IgG2a) to Human MAPK1 / ERK2
Mouse, Human, Primate
ICC, IF, IHC, WB
Unconjugated
100µg   $425.00
MAPK1 / ERK2 Antibody - IHC (P) using p42 MAP Kinase / ERK2 / MAPK1 Antibody (6F8)
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Mouse Monoclonal [clone 6F8] (IgG2a) to Human MAPK1 / ERK2
Mouse, Dog, Rat, Primate, Human
ChrIP, IF, IHC, IHC-P, IP, WB
Unconjugated
100µg   $425.00
MAPK1 / ERK2 Antibody - IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-MAPK1 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI6F8] (IgG2a) to Human MAPK1 / ERK2
Dog, Rat, Human, Monkey
Flo, IHC, IHC-P, IP, WB
Unconjugated
100µl   1mg/ml   $345.00
MAPK1 / ERK2 Antibody - IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-MAPK1 mouse monoclonal antibody. (Dilution 1:50).
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Mouse Monoclonal [clone OTI6F8] (IgG2a) to Human MAPK1 / ERK2
Dog, Rat, Human, Monkey
Flo, IHC, IP, WB
Unconjugated, Carrier-free
100µg   $395.00
MAPK1 / ERK2 Antibody - Immunohistochemistry (IHC) analysis of paraffin-embedded Human Lung carcinoma (left) and breast carcinoma (right) showing cytoplasmic localization with DAB staining using ERK 2 Monoclonal Antibody.
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Mouse Monoclonal (IgG2a) to Human MAPK1 / ERK2
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl   $345.00
MAPK1 / ERK2 Antibody - Immunohistochemistry Dilution at 1:600 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal Goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated Secondary antibody and visualized using an HRP conjugated SP system.
Select
Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50µg   $285.00; 100µg   $385.00
Select
Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Human
ELISA, Flo, ICC, IF, IP, WB
Unconjugated
200µl   $575.00; 600µl   $1,140.00
MAPK1 / ERK2 Antibody - MAPK1 / ERK antibody Western blot of Fetal Brain lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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Rabbit Polyclonal to Human MAPK1 / ERK2
Xenopus, Chicken, Zebrafish, Pig, Horse, Rat, Bovine, Rabbit, Mouse, Goat, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
100µl   0.5mg/ml   $365.00
MAPK1 / ERK2 Antibody
Select
Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
Select
Mouse Monoclonal [clone GF1] (IgG2a) to Human MAPK1 / ERK2
Mouse, Human, Monkey
ELISA, IF, IHC, WB
Unconjugated
100µl   $465.00
Select
Rabbit Polyclonal to Human MAPK1 / ERK2
Human
ELISA, Flo, ICC, IF
Unconjugated
50µl   $245.00; 100µl   $305.00
Select
Mouse Monoclonal (IgG1) to Human MAPK1 / ERK2
Mouse, Human, Monkey
ELISA, ICC, IHC, WB
Unconjugated
50µl   1mg/ml   $315.00; 100µl   1mg/ml   $375.00; 200µl   1mg/ml   $435.00
MAPK1 / ERK2 Antibody - IHC of paraffin-embedded breast tissue using anti-MAPK1 mouse monoclonal antibody. (Dilution 1:50).
Select
Mouse Monoclonal [clone OTI9E9] (IgG1) to Human MAPK1 / ERK2
Human
IHC, IHC-P, IP, WB
Unconjugated
100µl   1.2mg/ml   $345.00

Viewing 1-25 of 195 items


If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).