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Unfortunately, the ELISA kit (ID:945) is no longer available.

Below is a list of ELISA kits to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



MAPK1 / ERK2

mitogen-activated protein kinase 1

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation.Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity.

Gene Name: mitogen-activated protein kinase 1
Family/Subfamily: Protein Kinase , MAPK
Synonyms: MAPK1, ERK, ERK-2, ERK2, MAP kinase 1, MAPK 2, MAPK2, MAP kinase isoform p42, MAPK 1, p41mapk, PRKM2, MAP kinase 2, p41, p42-MAPK, PRKM1, ERT1, p38, p40, p42MAPK, Protein tyrosine kinase ERK2
Target Sequences: NM_002745 NP_002736.3 P28482

Filtered By: None
Target
mapk1-erk2 (128)
Reactivity
Human (122)
Mouse (77)
Rat (75)
Bat (2)
Bovine (18)
Chicken (13)
Chimpanzee (9)
Dog (20)
Drosophila (2)
Gibbon (6)
Goat (6)
Guinea pig (14)
Hamster (9)
Horse (17)
Monkey (26)
Orangutan (6)
Pig (16)
Primate (2)
Rabbit (19)
Sheep (3)
Xenopus (7)
Zebrafish (10)
Application
IHC (22)
IHC-Fr (1)
IHC-P (23)
WB (117)
Flo (9)
ChrIP (1)
ELISA (53)
ICC (4)
IF (17)
IP (35)
PLA (1)
Host
rabbit (86)
mouse (40)
goat (1)
sheep (1)
Isotype
IgG (47)
IgG1 (19)
IgG1,k (3)
IgG2a (8)
IgG2a,k (7)
IgG2b,k (1)
Clonality
monoclonal mc (41)
polyclonal pc (87)
Clone
1C11 (1)
1D1 (1)
1D3 (1)
4C11 (1)
4C11C11C4 (1)
4C2 (1)
4D10 (1)
6E5 (1)
6F8 (2)
7C9 (1)
7E7 (1)
814CT5.4.2 (1)
9E9 (1)
9H1 (1)
GF1 (1)
IL-13 (1)
Format
Agarose Conjugated (1)
AP Conjugated (5)
APC Conjugated (5)
Biotin Conjugated (9)
FITC Conjugated (9)
HRP Conjugated (9)
Magnetic beads Conjugated (1)
PE Conjugated (5)
Sepharose Conjugated (1)
Unconjugated (83)
Epitope
C-Terminus (26)
pThr180/Tyr182 (8)
Internal (7)
N-Terminus (6)
aa148-197 (4)
aa104-342 (3)
aa154-183 (2)
aa310-360 (2)
Thr204 (1)
aa1-360 (1)
aa110-190 (1)
aa123-172 (1)
aa136-185 (1)
aa171-184 (1)
aa254-285 (1)
aa324-335 (1)
aa340 (1)
aa348-360 (1)
aa9-19 (1)
Publications
No (128)
Showing 1-25 out of 128 results
Anti-MAPK1 / ERK2 Antibody (C-Terminus) IHC-plus™ LS-B1633

Rabbit Polyclonal (IgG) to Rat MAPK1 / ERK2
Mouse, Rat, Human
IHC-P IP WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (phospho-Thr180/Tyr182) LS-C37285

Rabbit Monoclonal (IgG) to Human MAPK1 / ERK2
Mouse, Rat, Human, Monkey
ELISA Flo ICC IF IP WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (aa310-360) IHC-plus™ LS-B12182

Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Chicken, Bovine, Rabbit, Mouse, Dog, Rat, Horse, Human
IF IHC-P PLA WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (clone 4C11C11C4) IHC-plus™ LS-B2159

Mouse Monoclonal [clone 4C11C11C4] (IgG2a) to Human MAPK1 / ERK2
Human
ELISA IHC-Fr IHC-P WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (phospho-Thr180/Tyr182) LS-C16335

Mouse Monoclonal (IgG1) to Human MAPK1 / ERK2
Mouse, Rat, Human
Flo IP WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody LS-C16375

Rabbit Polyclonal (IgG) to Mouse MAPK1 / ERK2
Mouse, Rat, Human
IP WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody IHC-plus™ LS-B6240

Mouse Monoclonal (IgG1,k) to Human MAPK1 / ERK2
Mouse, Rat, Human
ELISA IHC-P WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (phospho-Thr180/Tyr182) LS-C89478

Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Drosophila, Rat, Mouse, Human, Monkey
IHC-P WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (clone 4C11) LS-C355316

Mouse Monoclonal [clone 4C11] (IgG2a) to Human MAPK1 / ERK2
Mouse, Human, Primate
ICC IF IHC WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody LS-C497771

Mouse Monoclonal to Human MAPK1 / ERK2
Human
Flo IF IHC WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (phospho-Thr180/Tyr182) LS-C16326

Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Human
ELISA Flo ICC IF IP WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (clone GF1) LS-C190284

Mouse Monoclonal [clone GF1] (IgG2a) to Human MAPK1 / ERK2
Mouse, Human, Monkey
ELISA IF IHC WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (clone 6F8) LS-C355144

Mouse Monoclonal [clone 6F8] (IgG2a) to Human MAPK1 / ERK2
Mouse, Dog, Rat, Primate, Human
ChrIP IF IHC-P IP WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (clone 4C2) LS-C114584

Mouse Monoclonal [clone 4C2] (IgG1) to Human MAPK1 / ERK2
Dog, Rat, Human, Monkey
IF IHC-P IP WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (clone IL-13) LS-C415206

Mouse Monoclonal [clone IL-13] (IgG1) to Human MAPK1 / ERK2
Mouse, Rat, Human
ELISA ICC IHC WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (clone 6F8) LS-C114567

Mouse Monoclonal [clone 6F8] (IgG2a) to Human MAPK1 / ERK2
Dog, Rat, Human, Monkey
Flo IHC-P IP WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (aa110-190) LS-C383421

Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Mouse, Rat, Human
ELISA IF IHC WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (N-Terminus, Magnetic beads) LS-C171978

Rabbit Polyclonal to Human MAPK1 / ERK2
Human
IP
Magnetic beads Conjugated
Anti-MAPK1 / ERK2 Antibody IHC-plus™ LS-B7927

Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Mouse, Rat, Human
IHC-P WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (clone 7E7) LS-C114585

Mouse Monoclonal [clone 7E7] (IgG1) to Human MAPK1 / ERK2
Dog, Rat, Human, Monkey
IF IP WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody LS-C16323

Rabbit Polyclonal (IgG) to Human MAPK1 / ERK2
Mouse, Rat, Human
ELISA Flo IHC-P WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (clone 1D1) LS-C197993

Mouse Monoclonal [clone 1D1] (IgG1,k) to Human MAPK1 / ERK2
Human
ELISA IF WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (aa1-360) LS-C129480

Mouse Monoclonal (IgG2b,k) to Human MAPK1 / ERK2
Human
ELISA IF WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody LS-C203045

Rabbit Polyclonal to Human MAPK1 / ERK2
Mouse, Rat, Human
ELISA Flo WB
Unconjugated
Anti-MAPK1 / ERK2 Antibody (clone 9E9) LS-C114566

Mouse Monoclonal [clone 9E9] (IgG1) to Human MAPK1 / ERK2
Human
IHC-P IP WB
Unconjugated

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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