MAP3K7 / TAK1

mitogen-activated protein kinase kinase kinase 7

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signal transduction of TRAF6, various cytokines including interleukin-1 (IL-1), transforming growth factor-beta (TGFB), TGFB-related factors like BMP2 and BMP4, toll-like receptors (TLR), tumor necrosis factor receptor CD40 and B-cell receptor (BCR). Ceramides are also able to activate MAP3K7/TAK1. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K1/MEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs, c-jun N-terminal kinases (JNKs) and I-kappa-B kinase complex (IKK). Both p38 MAPK and JNK pathways control the transcription factors activator protein-1 (AP-1), while nuclear factor-kappa B is activated by IKK. MAP3K7 activates also IKBKB and MAPK8/JNK1 in response to TRAF6 signaling and mediates BMP2-induced apoptosis. In osmotic stress signaling, plays a major role in the activation of MAPK8/JNK1, but not that of NF-kappa-B. Promotes TRIM5 capsid-specific restriction activity.

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ELISA Kits (9)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Custom (4)

Sandwich (1)

Target

MAP3K7 / TAK1 (9)

Reactivity

Human (6)

Mouse (5)

Rat (5)

Bovine (1)

Format

96-Well Microplate (4)

96-Well Strip Plate (5)

Publications

No (9)

Sample Type

Adherent Cell Cultures (4)

Cell Lysates (1)

Tissue Homogenates (1)

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Mouse/Human/Rat Phospho-MAP3K7 / TAK1 (Thr187) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1684

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$772

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Mouse/Human/Rat MAP3K7 / TAK1 (Cell-Based ELISA) ELISA Kit - LS-F2126

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Mouse/Human/Rat Phospho-MAP3K7 / TAK1 (Ser439) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1685

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Rat MAP3K7 / TAK1 (Custom) ELISA Kit - LS-F66230

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Price:

1 Plate/$783

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Human MAP3K7 / TAK1 (Custom) ELISA Kit - LS-F66342

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Human

Price:

1 Plate/$783

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Human MAP3K7 / TAK1 (Sandwich ELISA) ELISA Kit - LS-F55619

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$834

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Bovine MAP3K7 / TAK1 (Custom) ELISA Kit - LS-F65879

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Bovine

Price:

1 Plate/$783

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Mouse MAP3K7 / TAK1 (Custom) ELISA Kit - LS-F66009

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Price:

1 Plate/$783

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Mouse/Human/Rat Phospho-MAP3K7 / TAK1 (Thr184) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1410

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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