MAP3K5 / ASK1

mitogen-activated protein kinase kinase kinase 5

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).

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Products

Proteins (6)

Type

Over-Expression Lysate (2)

Recombinant (4)

Target

MAP3K5 / ASK1 (6)

Publications

No (6)

Tag

GST, N-terminus (1)

His-T7 (2)

Myc-DDK (Flag) (3)

Species

Human (4)

Mouse (1)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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Mouse MAP3K5 / ASK1 Protein (Recombinant His-T7) (aa693-933) - LS-G13707

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.8 kDa

Price:

10 µg/$284; 50 µg/$462; 100 µg/$737; 200 µg/$922; 1 mg/$2,042; 500 µg/$1,577; 5 mg/$3,221; 2 mg/$2,231

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Human MAP3K5 / ASK1 Protein (Recombinant His-T7) (aa681-936) - LS-G24290

Source:

E. coli

Tag:

His-T7

Molecular Weight:

32.2 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human MAP3K5 / ASK1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66302

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

154.4 kDa

Price:

20 µg/$1,107

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Human MAP3K5 / ASK1 Protein (Recombinant GST, N-terminus) (aa1231-1374) - LS-G59221

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAP3K5 / ASK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77408

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

154.4 kDa

Price:

20 µg/$150

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MAP3K5 / ASK1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100678

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

154.4 kDa

Price:

100 µg/$494

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