MAP3K4 / MEKK4

mitogen-activated protein kinase kinase kinase 4

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Several alternatively spliced transcripts encoding distinct isoforms have been described.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

MAP3K4 / MEKK4 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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MAP3K4 / MEKK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G115649

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

181.6 kDa

Price:

100 µg/$710

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Human MAP3K4 / MEKK4 Protein (Recombinant GST, N-terminus) (aa1201-1300) - LS-G59220

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human MAP3K4 / MEKK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G80039

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

181.6 kDa

Price:

20 µg/$215

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