MAP3K3 / MEKK3

mitogen-activated protein kinase kinase kinase 3

MAP3K3 / MEKK3 is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

☰ Filters

Products

Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

MAP3K3 / MEKK3 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

His, N-Terminal (1)

Myc-DDK (Flag) (2)

Species

Human (4)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

Select

Human MAP3K3 / MEKK3 Protein (Recombinant GST, N-terminus) (aa1-89) - LS-G59219

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human MAP3K3 / MEKK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G77236

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.7 kDa

Price:

20 µg/$150

Select

Human MAP3K3 / MEKK3 Protein (Recombinant GST) (Full Length) - LS-G29309

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

35.64 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human MAP3K3 / MEKK3 Protein (Recombinant His, N-Terminal) - LS-G144106

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

70.7 kDa

Price:

50 µg/$419

Select

MAP3K3 / MEKK3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G118007

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

70.7 kDa

Price:

100 µg/$494

Viewing 1-5 of 5 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.