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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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MAP3K2 / MEKK2

mitogen-activated protein kinase kinase kinase 2

MEKK2, a MAP3K type protein kinase, is a member of MAP kinase signaling pathways. The protein contains a C-terminal protein kinase domain and a non-catalytic N-terminal domain. MEKK2 has been shown to regulate both JNK and ERK cascades by phosphorylating and activating either MKK4/MAP2K4 or MEK1/MAP2K1, respectively. Additionally, MEKK2 has been shown to directly phosphorylate and activate Ikappa B kinases (IKKs) of the immune and inflammatory response NF-kappa B signaling pathway and to bind and activate protein kinase C-related kinase 2. MEKK2 (-/-) embryonic stem cell-derived mast cells demonstrate that this protein is required for cytokine production and receptor-mediated stimulation of JNK.

Gene Name: mitogen-activated protein kinase kinase kinase 2
Family/Subfamily: Protein Kinase , MAP3K
Synonyms: MAP3K2, MAP/ERK kinase kinase 2, MAPK/ERK kinase kinase 2, MAPKKK2, MEK kinase 2, MEKK 2, MEKK2, MEKK2B
Target Sequences: NM_006609 NP_006600.3 Q9Y2U5

Filtered by: None
Type
Over-Expression Lysate (2)
Recombinant (3)
Target
MAP3K2 / MEKK2 (5)
Tag
GST,N-terminus (1)
Myc + DDK (3)
Species
Human (4)
Source
293T Cells (1)
HEK 293 Cells (2)
Insect Cells (1)
Wheat Germ Extract (1)
Biologically Active
Biologically active (1)
Showing 1-5 of 5 results

MAP3K2 / MEKK2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G115196
HEK 293 Cells
Myc + DDK
69.6 kDa
100µg  $475.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human MAP3K2 / MEKK2 Protein (Recombinant Myc + DDK) (Full Length) - LS-G70366
HEK 293 Cells
Myc + DDK
69.6 kDa
20µg  $815.00
Purified recombinant protein MAP3K2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining

Human MAP3K2 / MEKK2 Protein (Recombinant GST,N-terminus) (aa111-200) - LS-G61628
Wheat Germ Extract
GST,N-terminus
10µg  $425.00; 25µg  $590.00
12.5% SDS-PAGE Stained with Coomassie Blue.

Human MAP3K2 / MEKK2 Protein (Over-Expression Lysate Myc + DDK) (Full Length) - LS-G86894
293T Cells
Myc + DDK
69.6 kDa
20µg  $195.00
Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate

Human MAP3K2 / MEKK2 Protein (Recombinant) - LS-G131802
Insect Cells
None
Biologically active
~115 kDa
10µg  $365.00
Showing 1-5 of 5 results

Selected:

If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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