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MAP2K5 / MEK5
mitogen-activated protein kinase kinase 5
MAP2K5 / MEK5 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
| Gene Name: | mitogen-activated protein kinase kinase 5 |
| Family/Subfamily: | Protein Kinase , MAP2K |
| Synonyms: | MAP2K5, HsT17454, MAPKK 5, MEK 5, MAPKK5, MEK5, MKK5, MAP kinase kinase 5, PRKMK5, MAP kinase kinase MEK5b, MAPK/ERK kinase 5 |
| Target Sequences: | NM_145160 NP_660143.1 Q13163 |
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