Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
MAP2K5 / MEK5 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described.
|Gene Name:||mitogen-activated protein kinase kinase 5|
|Family/Subfamily:||Protein Kinase , MAP2K|
|Synonyms:||MAP2K5, HsT17454, MAPKK 5, MEK 5, MAPKK5, MEK5, MKK5, MAP kinase kinase 5, PRKMK5, MAP kinase kinase MEK5b, MAPK/ERK kinase 5|
|Target Sequences:||NM_145160 NP_660143.1 Q13163|
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