MAP2K4 / MKK4

mitogen-activated protein kinase kinase 4

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14.

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Products

Proteins (8)

Type

Over-Expression Lysate (2)

Recombinant (6)

Target

MAP2K4 / MKK4 (8)

Publications

No (8)

Tag

GST (1)

GST, N-terminus (1)

His-GST (2)

His-SUMO (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Mouse (2)

Source

293T Cells (1)

Baculovirus (1)

E. coli (2)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (2)

Low Endotoxin Level

Low endotoxin level (1)

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Human MAP2K4 / MKK4 Protein (Recombinant GST, N-terminus) (aa1-100) - LS-G60066

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Mouse MAP2K4 / MKK4 Protein (Recombinant His-SUMO) (Full Length) - LS-G20946

Source:

E. coli

Tag:

His-SUMO

Molecular Weight:

60 kD

Price:

1 mg/$1,679; 100 µg/$500; 20 µg/$364

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Human MAP2K4 / MKK4 Protein (Recombinant GST) (Full Length) - LS-G30376

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

70.8 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MAP2K4 / MKK4 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G66120

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

20 µg/$1,107

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Human MAP2K4 / MKK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G76963

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

20 µg/$150

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MAP2K4 / MKK4 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99942

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

44.1 kDa

Price:

100 µg/$494

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Mouse MAP2K4 / MKK4 Protein (Recombinant His-GST) (Ala2-Asp397) - LS-G98813

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

72 kDa

Price:

50 µg/$502

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Human MAP2K4 / MKK4 Protein (Recombinant His-GST) (aa137-394) - LS-G15353

Source:

E. coli

Tag:

His-GST

Molecular Weight:

61.3 kDa

Price:

10 µg/$277; 50 µg/$417; 100 µg/$667; 200 µg/$832; 1 mg/$1,922; 500 µg/$1,470; 5 mg/$2,913; 2 mg/$2,107

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