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MAP2K2 / MKK2 / MEK2

mitogen-activated protein kinase kinase 2

MAP2K2 / MKK2 / MEK2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Gene Name: mitogen-activated protein kinase kinase 2
Family/Subfamily: Protein Kinase , MAP2K
Synonyms: MAP2K2, ERK activator kinase 2, MAP kinase kinase 2, MAPK/ERK kinase 2, MAPKK 2, MKK2, MEK 2, MEK2, MAPKK2, PRKMK2
Target Sequences: NM_030662 NP_109587.1 P36507

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Products
Proteins (10)
Over-Expression Lysate (2)
Recombinant (8)
MAP2K2 / MKK2 / MEK2 (10)
No (10)
GST (2)
GST, N-terminus (2)
His (1)
His-T7 (2)
Myc-DDK (Flag) (3)
Human (8)
Mouse (1)
293T Cells (1)
Baculovirus (1)
E. coli (3)
HEK 293 Cells (2)
Wheat Germ Extract (3)
Purified (3)
Low endotoxin level (1)
MAP2K2 / MKK2 / MEK2 Protein - Recombinant Mitogen Activated Protein Kinase Kinase 2 By SDS-PAGE
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E. coli
His-T7
33.7 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
MAP2K2 / MKK2 / MEK2 Protein - Purified recombinant protein MAP2K2 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
44.2 kDa
20 µg/$1,107
MAP2K2 / MKK2 / MEK2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
MAP2K2 / MKK2 / MEK2 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
Select
293T Cells
Myc-DDK (Flag)
44.2 kDa
20 µg/$150
Select
Baculovirus
GST
Less than 1.0 EU/µg protein (determined by LAL method).
70.7 kDa
50 µg/$502
MAP2K2 / MKK2 / MEK2 Protein - Recombinant  Mitogen Activated Protein Kinase Kinase 2 By SDS-PAGE
Select
E. coli
His-T7
31.2 kDa
10 µg/$285; 50 µg/$470; 100 µg/$750; 200 µg/$937; 1 mg/$2,063; 500 µg/$1,594; 5 mg/$3,277; 2 mg/$2,252
MAP2K2 / MKK2 / MEK2 Protein - 12.5% SDS-PAGE of human MAP2K2 stained with Coomassie Blue
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Wheat Germ Extract
GST
70.8 kDa
10 µg/$479; 25 µg/$670
MAP2K2 / MKK2 / MEK2 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
44.2 kDa
100 µg/$494
MAP2K2 / MKK2 / MEK2 Protein
Select
E. coli
His
10 µg/$361; 50 µg/$739; 20 µg/$486; 100 µg/$1,177; 250 µg/$1,788; 500 µg/$3,043
Viewing 1-10 of 10 product results


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If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).