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MAP2K2 / MKK2 / MEK2

mitogen-activated protein kinase kinase 2

MAP2K2 / MKK2 / MEK2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Gene Name: mitogen-activated protein kinase kinase 2
Family/Subfamily: Protein Kinase , MAP2K
Synonyms: MAP2K2, ERK activator kinase 2, MAP kinase kinase 2, MAPK/ERK kinase 2, MAPKK 2, MKK2, MEK 2, MEK2, MAPKK2, PRKMK2
Target Sequences: NM_030662 NP_109587.1 P36507

☰ Filters
Products
Antibodies (154)
Primary (154)
MAP2K2 / MKK2 / MEK2 (154)
Human (146)
Mouse (100)
Rat (80)
Chimpanzee (6)
Dog (7)
Gibbon (6)
Monkey (8)
IHC (47)
IHC-P (17)
WB (140)
Flo (8)
DB (7)
ELISA (73)
ICC (6)
IF (21)
IP (15)
Peptide-ELISA (2)
rabbit (112)
mouse (41)
goat (1)
Product Group
IHCPlus (1)
IgG (86)
IgG1 (13)
IgG1,k (9)
IgG2a (4)
IgG2b (1)
IgG2b,k (9)
monoclonal mc (41)
polyclonal pc (113)
01 (1)
12A6.G1.G11 (8)
19G10.F1.E2 (8)
7F5 (2)
8D10 (1)
BNHE (1)
BUI3 (1)
OTI1A2 (2)
OTI5B4 (2)
OTI5F6 (2)
OTI5G8 (2)
OTI8G6 (2)
AP Conjugated (4)
APC (2)
APC Conjugated (6)
Azide-free (3)
Biotin Conjugated (17)
Carrier-free (5)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (17)
HRP Conjugated (17)
Liquid (12)
Lyophilized (12)
PE Conjugated (6)
Preservative Free (1)
Unconjugated (83)
N-Terminus (21)
C-Terminus (20)
aa262-292 (8)
aa36-63 (8)
aa44-313 (8)
aa86-331 (8)
pSer222 (7)
pThr394 (5)
aa1-50 (2)
340-420 aa (1)
Arg388 (1)
Ser218 (1)
aa2-20 (1)
aa261-310 (1)
aa350-400 (1)
aa359-372 (1)
p394 (1)
No (154)
MAP2K2 / MKK2 / MEK2 Antibody - Immunohistochemistry of paraffin-embedded mouse kidney using MAP2K1/MAP2K2 antibodyat dilution of 1:100 (40x lens).
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
IF, IHC, IP, WB
Unconjugated
50 µl/$333; 100 µl/$429; 200 µl/$574
MAP2K2 / MKK2 / MEK2 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-MAP2K2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal (OTI1A2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K2 / MKK2 / MEK2 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-MAP2K2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal (Carrier-free) (OTI1A2) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$448
MAP2K2 / MKK2 / MEK2 Antibody - MEK2 Antibody in Immunofluorescence (IF)
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal (7F5) Antibody
Mouse, Rat, Human
Flo, ICC, IF, WB
Unconjugated
100 µl/$486
MAP2K2 / MKK2 / MEK2 Antibody - IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-MAP2K2 mouse monoclonal antibody. (Dilution 1:50).
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal (OTI5F6) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K2 / MKK2 / MEK2 Antibody - IHC of paraffin-embedded Adenocarcinoma of breast tissue using anti-MAP2K2 mouse monoclonal antibody. (Dilution 1:50).
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal (Carrier-free) (OTI5F6) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$448
MAP2K2 / MKK2 / MEK2 Antibody - IHC of paraffin-embedded Carcinoma of pancreas tissue using anti-MAP2K2 mouse monoclonal antibody. (Dilution 1:50).
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal (OTI8G6) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$390
MAP2K2 / MKK2 / MEK2 Antibody - IHC of paraffin-embedded Carcinoma of pancreas tissue using anti-MAP2K2 mouse monoclonal antibody. (Dilution 1:50).
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal (Carrier-free) (OTI8G6) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$448
MAP2K2 / MKK2 / MEK2 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal (aa262-292) Antibody
Mouse, Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$376
MAP2K2 / MKK2 / MEK2 Antibody - Immunohistochemistry of paraffin-embedded human liver cancer using MAP2K2 Antibody at dilution of 1:100
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$284; 100 µg/$351
MAP2K2 / MKK2 / MEK2 Antibody - Immunofluorescence (IF) analysis of HeLa cells using MEK-2 Monoclonal Antibody (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, Flo, IF, WB
Unconjugated
100 µl/$371
MAP2K2 / MKK2 / MEK2 Antibody - Immunofluorescence of HeLa cells using anti-MAP2K2 monoclonal antibody (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye.
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal (7F5) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
100 µl/$395
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal Antibody
Mouse, Rat, Human
ELISA, Flo, ICC, WB
Unconjugated
50 µl/$351; 100 µl/$411; 200 µl/$471
MAP2K2 / MKK2 / MEK2 Antibody - Immunofluorescence staining of MAP2K2 in MCF7 cells. Cells were fixed with 4% PFA, permeabilzed with 0.1% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human MAP2K2 polyclonal antibody (dilution ratio 1:200) at 4°C overnight. Then cells were stained with the Alexa Fluor 488-conjugated Goat Anti-rabbit IgG secondary antibody (green) and counterstained with DAPI (blue). Positive staining was localized to Cytoplasm.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IP, WB
Unconjugated
50 µl/$275; 100 µl/$312; 200 µl/$350
MAP2K2 / MKK2 / MEK2 Antibody - 1:100 staining rat lung tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µl/$369; 200 µl/$411
MAP2K2 / MKK2 / MEK2 Antibody - Anti-MAP2K2 / MEK2 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
MAP2K2 / MKK2 / MEK2 Antibody - 1:100 staining human breast carcinoma tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal (pThr394) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
100 µl/$369; 200 µl/$411
MAP2K2 / MKK2 / MEK2 Antibody - Immunofluorescence of monoclonal antibody to MAP2K2 on HeLa cell . [antibody concentration 10 ug/ml]
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MAP2K2 / MKK2 / MEK2 Mouse anti-Human Monoclonal (8D10) Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$407
MAP2K2 / MKK2 / MEK2 Antibody - Western blot of MEK-2 antibody
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal (340-420 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
MAP2K2 / MKK2 / MEK2 Antibody - Western Blot (WB) analysis of VEC cells using Phospho-MEK-2 (T394) polyclonal antibody.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, IP, WB
Unconjugated
50 µl/$277; 100 µl/$308; 200 µl/$374
MAP2K2 / MKK2 / MEK2 Antibody - Immunohistochemistry of paraffin-embedded Human gastric cancer using MAP2K2 Polyclonal Antibody at dilution of 1:100.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$242; 60 µl/$278; 120 µl/$338; 200 µl/$440
MAP2K2 / MKK2 / MEK2 Antibody - Western blot analysis of extracts of HeLa cells, using MAP2K2 antibody. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
100 µl/$333; 200 µl/$429
MAP2K2 / MKK2 / MEK2 Antibody - Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using MEK2 Antibody. The picture on the right is blocked with the synthesized peptide.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal (aa261-310) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, Peptide-ELISA, WB
Unconjugated
50 µl/$306; 100 µl/$366
MAP2K2 / MKK2 / MEK2 Antibody - IHC of MEK2 (R388) pAb in paraffin-embedded human breast carcinoma tissue.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal (Arg388) Antibody
Mouse, Rat, Human
IHC, IHC-P, IP, WB
Unconjugated
50 µl/$319; 100 µl/$393
MAP2K2 / MKK2 / MEK2 Antibody - Immunohistochemical analysis of MKK2 (pT394) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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MAP2K2 / MKK2 / MEK2 Rabbit anti-Human Polyclonal (pThr394) Antibody
Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
100 µl/$305
Viewing 1-25 of 154 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).