MAP2K1 / MKK1 / MEK1

mitogen-activated protein kinase kinase 1

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context, this pathway mediates diverse biological functions such as cell growth, adhesion, survival and differentiation, predominantly through the regulation of transcription, metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), as well as in the fragmentation of the Golgi apparatus during mitosis.

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Products

ELISA Kits (17)

Type

Cell-Based (1)

Cell-Based Phosphorylation (3)

Custom (2)

Sandwich (10)

Sandwich CLIA (1)

Target

MAP2K1 / MKK1 / MEK1 (17)

Reactivity

Human (9)

Mouse (5)

Rat (6)

Chicken (1)

Monkey (1)

Porcine (1)

Rabbit (1)

Sheep (1)

Format

12 x 8-Well Microstrips (1)

96-Well Microplate (5)

96-Well Strip Plate (11)

Publications

No (17)

Sample Type

Adherent Cell Cultures (4)

Cell Lysates (1)

Plasma (4)

Serum (4)

Tissue Homogenates (3)

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Monkey MAP2K1 / MKK1 / MEK1 (Sandwich ELISA) ELISA Kit - LS-F45753

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Monkey

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Chicken MAP2K1 / MKK1 / MEK1 (Sandwich ELISA) ELISA Kit - LS-F45752

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Chicken

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Sheep MAP2K1 / MKK1 / MEK1 (Sandwich ELISA) ELISA Kit - LS-F45755

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Sheep

Range:

0.781 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$760

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Rabbit MAP2K1 / MKK1 / MEK1 (Sandwich ELISA) ELISA Kit - LS-F45756

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rabbit

Range:

62.5 - 4000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Porcine MAP2K1 / MKK1 / MEK1 (Sandwich ELISA) ELISA Kit - LS-F45754

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Porcine

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$728

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Rat MAP2K1 / MKK1 / MEK1 (Sandwich ELISA) ELISA Kit - LS-F39033

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Rat

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Cell Lysates, Tissue Homogenates

Price:

1 Plate/$893

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Rat MAP2K1 / MKK1 / MEK1 (Custom ELISA) ELISA Kit - LS-F16001

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Mouse MAP2K1 / MKK1 / MEK1 (Custom ELISA) ELISA Kit - LS-F16002

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Human MAP2K1 / MKK1 / MEK1 (Sandwich ELISA) ELISA Kit - LS-F12075

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$685

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Human MAP2K1 / MKK1 / MEK1 (Sandwich ELISA) ELISA Kit - LS-F20937

Type:

Sandwich

Format:

96-Well Microplate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$651

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Human MAP2K1 / MKK1 / MEK1 (Sandwich ELISA) ELISA Kit - LS-F34604

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Human MAP2K1 / MKK1 / MEK1 (CLIA) ELISA Kit - LS-F29438

Type:

Sandwich CLIA

Format:

12 x 8-Well Microstrips

Reactivity:

Human

Range:

31.25 - 2000 pg/ml

Detection:

Chemiluminescent

Sample Types:

Plasma, Serum

Price:

1 Plate/$728

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Mouse/Human/Rat Phospho-MAP2K1 / MKK1 / MEK1 (Ser298) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1259

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat Phospho-MAP2K1 / MKK1 / MEK1 (Thr286) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1260

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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Mouse/Human/Rat MAP2K1 / MKK1 / MEK1 (Cell-Based ELISA) ELISA Kit - LS-F2139

Type:

Cell-Based

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$618

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Human MAP2K1 / MKK1 / MEK1 (Sandwich ELISA) ELISA Kit - LS-F7448

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Tissue Homogenates

Price:

1 Plate/$834

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Mouse/Human/Rat Phospho-MAP2K1 / MKK1 / MEK1 (Thr291) (Cell-Based Phosphorylation ELISA) ELISA Kit - LS-F1561

Type:

Cell-Based Phosphorylation

Format:

96-Well Microplate

Reactivity:

Mouse, Human, Rat

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Adherent Cell Cultures

Price:

1 Plate/$668

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