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MAP1B

microtubule-associated protein 1B

Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.

Gene Name: microtubule-associated protein 1B
Synonyms: MAP1B, FUTSCH, MAP-1B, MAP5
Target Sequences: NM_005909 NP_005900.2 P46821

Publications (4)

1
Glycogen synthase kinase-3beta phosphorylation of MAP1B at Ser1260 and Thr1265 is spatially restricted to growing axons. Trivedi N, Marsh P, Goold RG, Wood-Kaczmar A, Gordon-Weeks PR. Journal of cell science. 2005 118:993-1005. [PubMed:15731007]
2
Nonprimed and DYRK1A-primed GSK3 beta-phosphorylation sites on MAP1B regulate microtubule dynamics in growing axons. Scales TM, Lin S, Kraus M, Goold RG, Gordon-Weeks PR. Journal of cell science. 2009 122:2424-35. [PubMed:19549690] [PMC:PMC2704879]
3
Evolution of the spatial distribution of MAP1B phosphorylation sites in vertebrate neurons. Tymanskyj SR, Lin S, Gordon-Weeks PR. Journal of anatomy. 2010 216:692-704. [PubMed:20408908] [PMC:PMC2952382]
4
MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network. Marchbank K, Waters S, Roberts RG, Solomon E, Whitehouse CA. International journal of cell biology. 2012 2012:208014. (ICC; Rat) [PubMed:22654911] [PMC:PMC3357945]
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MAP1B ELISA Kit
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0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$783
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78.125 - 5000 pg/ml
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1 Plate/$651
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0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
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1 Plate/$783
MAP1B ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).