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Immunohistochemistry Services

Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

TCR Screening Services

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

Research Areas
Cell Cycle Pathways
Protein Family And Group
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MANF / ARMET

mesencephalic astrocyte-derived neurotrophic factor

MANF / ARMET is localized in the endoplasmic reticulum (ER) and golgi, and is also secreted. Reducing expression of this gene increases susceptibility to ER stress-induced death and results in cell proliferation. Activity of this protein is important in promoting the survival of dopaminergic neurons. The presence of polymorphisms in the N-terminal arginine-rich region, including a specific mutation that changes an ATG start codon to AGG, have been reported in a variety of solid tumors; however, these polymorphisms were later shown to exist in normal tissues and are thus no longer thought to be tumor-related.

Gene Name: mesencephalic astrocyte-derived neurotrophic factor
Synonyms: MANF, ARP, ARMET, Arginine-rich protein, Protein ARMET
Target Sequences: NM_006010 NP_006001.4 P55145

Publications (3)

1
Piperine ameliorates SCA17 neuropathology by reducing ER stress. Guo J, Cui Y, Liu Q, Yang Y, Li Y, Weng L, Tang B, Jin P, Li XJ, Yang S, Li S. Molecular neurodegeneration. 2018 January;13:4. (Human) [Full Text Article] [PubMed:29378605] [PMC:PMC5789626] Related Antibodies: LS-B2688.
2
Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Upregulated with Therapeutic Fasting in Humans and Diet Fat Withdrawal in Obese Mice. Galli E, Rossi J, Neumann T, Andressoo JO, Drinda S, Lindholm P. Science advances. 2019 October;9:14318. [Full Text Article] [PubMed:31586115] [PMC:PMC6778185] Related Antibodies: LS-B2688.
3
Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) Is Highly Expressed in Mouse Tissues With Metabolic Function. Danilova T, Galli E, Pakarinen E, Palm E, Lindholm P, Saarma M, Lindahl M. Frontiers in endocrinology. 2019 November;10: [Full Text Article] [PubMed:31781038] [PMC:PMC6851024] Related Antibodies: LS-B2688.


MANF / ARMET Antibody - Anti-MANF / ARMET antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Mouse, Rat, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05mg   1mg/ml   $545.00
MANF / ARMET Antibody - Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
IF, IHC, IHC-P, WB
Unconjugated
50µl   $425.00
MANF / ARMET Antibody - Immunohistochemistry of MANF in human brain tissue with MANF antibody at 2.5 ug/ml.
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Mouse, Rat, Human
ELISA, IF, IHC, WB
Unconjugated
50µg   1mg/ml   $365.00
MANF / ARMET Antibody - Immunochemical staining of human MANF in human brain with rabbit polyclonal antibody at 1:1000 dilution, formalin-fixed paraffin embedded sections.
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
ELISA, ICC, IF, IHC-P
Unconjugated, Preservative Free
50µl   $235.00; 100µl   $275.00; 200µl   $305.00
MANF / ARMET Antibody - Immunohistochemistry of ARP antibody
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50µl   1mg/ml   $235.00; 100µl   1mg/ml   $265.00; 200µl   1mg/ml   $335.00
Select
Rabbit Polyclonal to Human MANF / ARMET
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
100µl   $385.00
MANF / ARMET Antibody - Immunohistochemistry of paraffin-embedded human endometrial cancer using antibody at 1:100 dilution.
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
ELISA, IHC, IHC-P
Unconjugated
50µl   $285.00; 100µl   $385.00
MANF / ARMET Antibody - Immunohistochemistry of paraffin-embedded human liver using MANF antibody at dilution of 1:100 (40x lens).
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
IHC, WB
Unconjugated
20µl   $215.00; 50µl   $235.00; 100µl   $295.00; 200µl   $385.00
Select
Rabbit-New Zealand White Polyclonal to Mouse MANF / ARMET
Mouse, Rat, Human
IHC, WB
Unconjugated
100µl   $325.00
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
IF, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
IHC, WB
Unconjugated
60µl   1mg/ml   $235.00; 120µl   1mg/ml   $295.00; 200µl   1mg/ml   $395.00
MANF / ARMET Antibody - Immunohistochemistry of paraffin-embedded Human colon cancer using MANF Polyclonal Antibody at dilution of 1:70.
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl   0.1mg/ml   $205.00; 60µl   0.1mg/ml   $235.00; 120µl   0.1mg/ml   $295.00; 200µl   0.1mg/ml   $395.00
MANF / ARMET Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using MANF Polyclonal Antibody at dilution of 1:50.
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20µl   0.4mg/ml   $205.00; 60µl   0.4mg/ml   $235.00; 120µl   0.4mg/ml   $295.00; 200µl   0.4mg/ml   $395.00
MANF / ARMET Antibody - Detection limit for recombinant GST tagged ARMET is 0.03 ng/ml as a capture antibody.
Select
Mouse Monoclonal [clone 1D10] (IgG1,k) to Human MANF / ARMET
Human
ELISA, WB
Unconjugated
100µg   $365.00
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
ELISA, WB
Unconjugated
200µl   $590.00
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
ELISA, WB
Biotin Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
ELISA, WB
FITC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
ELISA, WB
APC Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
ELISA, WB
AP Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
ELISA, WB
PE Conjugated
200µl   $740.00
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Human
ELISA, WB
HRP Conjugated, Azide-free
200µl   $740.00
MANF / ARMET Antibody - Western blot analysis of lysate from 293 cells, using MANF Antibody.
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Mouse, Rat, Human
ELISA, WB
Unconjugated
50µg   1mg/ml   $265.00; 100µg   1mg/ml   $325.00
MANF / ARMET Antibody - Western blot analysis of extracts of HepG2 cells using ARMET antibody. The lane on the left was treated with blocking peptide.
Select
Rabbit Polyclonal (IgG) to Human MANF / ARMET
Mouse, Rat, Human
ELISA, WB
Unconjugated
100µl   1mg/ml   $325.00; 200µl   1mg/ml   $375.00
MANF / ARMET Antibody - Rabbit antibody to MANF (20-70). IHC-P on paraffin sections of rat testis. The animal was perfused using Autoperfuser at a pressure of 110 mm Hg with 300 ml 4% FA and further post fixed overnight before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered through a 0.2 micron filter. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions. Primary antibody: dilution 1:1000, incubated 30 min at RT (using Autostainer). Sections were counterstained with Harris Hematoxylin.
Select
Rabbit Polyclonal to Mouse MANF / ARMET
Mouse, Rat, Human
IHC
Unconjugated
100µl   $325.00
Select
Rabbit Polyclonal to Mouse MANF / ARMET
Mouse
ELISA
Unconjugated
50µl   $245.00; 100µl   $305.00
Viewing 1-25 of 46 products



If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).