MAML2

mastermind-like 2 (Drosophila)

MAML2 is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

MAML2 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

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Human (2)

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293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human MAML2 Protein (Recombinant GST, N-terminus) (aa796-894) - LS-G63373

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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MAML2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G108817

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

125 kDa

Price:

100 µg/$710

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Human MAML2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85935

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

125 kDa

Price:

20 µg/$215

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