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Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions.
Gene Name: | mastermind-like 1 (Drosophila) |
Synonyms: | MAML1, Mam1, Mastermind homolog, Mastermind-like protein 1, Mastermind (drosophila)-like 1, Mastermind-like 1 (Drosophila), KIAA0200, Mam-1 |
Target Sequences: | NM_014757 NP_055572.1 Q92585 |
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